Cholesterol

aceteoacetyl-CoA goes to ?

3-hydroxy-3-methylglutaryl-CoA (HMG-CoA)

What’s my rate limiting steps

HMG-CoA reductase

What inhibits HMG-CoA reductase

statins

AMP

Glucagon

Cholesterol essentially

What inhibits SCAP—>SREBP—>synthesis of HMG reductase

Cholesterol

What activates HMG-CoA reductase ?

Insulin

HMG-CoA goes to ?

6-C mevalonate

IPP goes to?

FPP

squalence to ?

Lanosterol

Lanosterol to cholesterol in how many steps

19 rxns

Acetyl-CoA and acetyl-CoA to aceteoacetyl-CoA through was enzyme

thiolase

Cholesterol products

Bile acids

Steroid hormones

Vitamin D

what’s the rate limiting step in bile acids

7-a-hydroxylase

What inhibits 7-a-hydroxylase

Bile acids

What’s primary bile acids

chenodeoxy colic acid

colic acid

Secondary bile

deoxycholate and litocholate

Bile acid functions

Excrete feces

Solubility cholesterol in bile preventing precipitation of cholesterol in gallbladder

Facilitate digestion of dietary TG

Absorption of fat soluble vitamins