Physicochemical properties and drug action 2

practice questions

will the following compound form a mono or dihydrochloride salt?

mono-

dissociates in vivo and forms and ion-dipole interaction with water

“-ate” in a salt name

indicates that the salt is an anion (neg charge)

so the drug it is associated with must be basic

stomach

small surface area

drugs are here for a shorter amount of time

pH = 1

duodenum

0.3 meters long

pH = 5-7

jejunum

2.5 meters long

pH = 7-8

ileum

3.5 meters long

pH = 7-8

small intestine: surface area contributers

folds of kerckring

villi

microvilli

precipitation may occur when mixing aqueous solutions of morphine sulfate with which of the following?

- sodium bicarbonate

- atropine sulfate

- phenytoin sodium

sodium bicarbonate and phenytoin sodium

albumin

plasma protein

binds strongly to acidic drugs (specifically those with carboxylic acids)

alpha 1 acid glycoprotein

plasma protein

binds primarily to basic drugs (amines) and hydrophobic drugs (steroids)