Virulence Factors of S. pyogenes

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Last updated 1:45 AM on 8/21/26
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8 Terms

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M protein

Encoded by emm gene; Prevents phagocytosis

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Streptolysin O

Antigenic (anti-streptolysin O), Oxygen labile, responsible for hemolysis on SBA plates incubated anaerobically

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Streptolysin S

Non-antigenic, Oxygen stable can cause hemolysis on SBA plates incubated aerobically

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Protein F

promotes attachment to epithelial cell

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Erythrogenic Toxin or Pyrogenic Toxin

causes rashes in scarlet fever

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Hyaluronidase

aka spreading factor

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Streptokinase

promotes fibrinolysis and is responsible for dissolution of clot

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Streptolysin

responsible for beta hemolysis