Acute Inflammation: Cellular Changes

Explain how Neutrophils reach injury site

• Hemodynamic

  • Margination, Rolling, Adhesion, Transmigration

• Cellular Changes:

  • Adhesion Molecules

  • Selectins, Integrins

  • ICAM-1; VCAM-1

  • Hemodynamic changes

• Chemical:

  • Bacterial Products

  • C5a

  • Leukotriene B4

  • Cehmokines IL8

  • Platelet Act. Factors

What are the roles of Selectins and Integrins

What are Weibel-palade bodies?

What does IL-1 do?

What increases Avidity of integrins?

List the Endothelial-leukocyte adhesion molecules

• Selectins

• ICAMs

• Integrins

• Addressins

• SELECTINS (endothelium, platelets, leukocytes)

  • E- and P- and L- selectin

• IMMUNOGLOBULINS (endothelium)

  • ICAM-1 and VCAM-1 (intercellular/vascular cell adhesion molecule)

• INTEGRINS (transmembrane receptors)

  • beta-Integrins (receptors for ICAM-1)

  • alpha-beta-Integrins (receptors for VCAM-1)

• ADDRESSINS: Mucin glycoproteins (endothelium, leukocytes)

  • PSGL-1 (P-selectin GP ligand)

  • ESL-1 (E-selectin ligand)

  • CD34

During Oxidative bursts, what causes Tissue Injury and Inflammaion?

How do we know its inflammaion, Clinically and in lab

• Clinically

  • Fever

• Laboratory

  • # of White blood cells in blood

  • ESR

  • C-reactive protein

What happen to serum proteins in Acute inflammation:

Acute inflammation:

• Serum albumin decreases

• Alpha 1 & 2 globulins increase