Detecting positive selection and molecular clocks

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6 Terms

1
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What are the methods to detect positive selection?

  • Ka/Ks test

  • McDonald-Kreitman (MK) test

  • Fixation index (Est)

  • Linkage disequilibrium (LD)

2
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What is the Ka/Ks test suitable for?

Suitable between species (Ka = non-synonymous, Ks = synonymous substitutions)

3
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What is the McDonald-Kreitman (MK) test for?

For comparison between species and within species

4
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What is the fixation index (Est) for?

Testing different in allele frequency between populations

5
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What is linkage disequilibrium (LD) for?

Look for non-random association of alleles at loci

6
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What are molecular clocks?

Changes in homologous proteins between species is directly proportional to time

<p>Changes in homologous proteins between species is directly proportional to time</p>