lipid lowering characteristics

statin indications

hyperlipidemia, primary/secondary prevention of atherosclerotic cardiovascular disease, familial hypercholesterolemia

statin mechanism

competitively inhibit conversion of HMG-CoA to mevalonate, an early rate limiting step in cholesterol synthesis. A compensatory increase in LDL receptor, which bind and remove circulating LDL-cholesterol

statin contraindications

breastfeeding and active liver disease, no bbw

statin ADR

c- myopathy, diarrhea

r- rhabdomyolysis, hepatotoxicity

statin counsel

this is used to lower bad cholesterol and raise good cholesterol, contact your doctor if you develop muscle pain

cholesterol absorption inhibitor indication

hyperlipidemia, familial hypercholesterolemia

cholesterol absorption inhibitor mechanism

inhibits the absorption of cholesterol at the brush border of the small intestine

cholesterol absorption inhibitor contraindications

gallbladder disease and severe hepatic dysfunction, no bbw

cholesterol absorption inhibitor ADR

c-none

r- rhabdomyolysis, hepatotoxicity

cholesterol absorption inhibitor counsel

this is used to lower bad cholesterol and raise good cholesterol, contact your doctor if you develop muscle pain

bile acid sequestrant indication

hyperlipidemia

bile acid sequestrant mechanism

binds with acids in the intestine to form an insoluble complex that is eliminated in the feces

bile acid sequestrant contraindications

history of bowel obstruction, triglycerides>500mg/dL, hypertriglyceridemia induced pancreatitis, no bbw

bile acid sequestrant ADR

c- constipation

r- pancreatitis, bowel obstruction

bile acid sequestrant counsel

this medication is used to lower cholesterol levels, take with food, packet/granules- mix with 120-240mL of water, stir well and drink, tablets-swallow with liquid

fibric acid indication

hyperlipidemia, hypertriglyceridemia

fibric acid mechanism

activate peroxisome proliferator-activated receptor alpha (PPARa) which increases lipolysis and elimination of triglyceride-rich particles from plasma

fibric acid contraindications

gallbladder disease, no bbw

fibric acid ADRs

c-increased transaminases

r- hepatotoxicity, rhabdomyolysis (especially in combination with a statin)

fibric acid counsel

this is used to lower LDL and TG and raise good cholesterol, this medication comes in many formulations, some require administration with food (fenoglide), contact your doctor if you develop muscle pain

antilipemic indication

hyperlipidemia

antilipemic mechanism

not well defined. may involve partial inhibition of release of free fatty acids from adipose tissue and increase lipoprotein lipase activity, which may increase the rate of chylomicron triglyceride removal from plasm. Niacin decreases the rate of hepatic synthesis of VLDL and LDL

antilipemic contraindications

severe hepatic dysfunction, peptic ulcer disease, no bbw

antilipemic ADRs

c-flushing, headache

r- hepatotoxicity, rhabdomyolysis

antilipemic counsel

this medication is used to lower cholesterol levels, you will start at a low dose and slowly increase over time to decrease side effects, to decrease flushing avoid alcohol and spicy foods while taking this medication

omega 3s indication

hyperlipidemia, hypertriglyceridemia

omega 3s mechanism

reduction in the hepatic production of triglyceride-rich very low density lipoprotein

omega 3s contraindication

hypersensitivity to drug, fish, or shellfish (use with caution) no bbw

omega 3s ADRs

c-diarrhea, fishy breath, burping, change in taste

r- elevated LFTs

omega 3s counsel

this is used to lower bad cholesterol, take with food