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Necrosis cell size
Enlargened (swollen)
Apoptosis cell size
Reduced (shrinkage)
Apoptosis nucleus
Fragmented into nucleosome sized pieces
Necrosis nucleus
Pyknosis
Karyorrhexis
Karyolysis
Necrosis plasma membrane
Ruptured
Apoptosis plasma membrane
Intact
Altered structure (especially orientation of lipids)
Necrosis cellular contents
Enzymatic digestion
May leak out of cell
Apoptosis cellular components
Intact
May be released into apoptotic bodies
Necrosis adjacent inflammation
Frequent
Apoptosis adjacent inflammation
No
Necrosis physiologic or pathologic
Pathologic
Culmination of irreversible cell injury
Apoptosis physiologic or pathologic
Physiologic
Eliminating unwanted cells may be pathologic after cell injury (especially dna damage)