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Cellular metabolism depends on
cell size
What happens when a cell gets too large?
it begins to be difficult to regulate what comes in and out of the cell
The size of the cell will determine
it's function
Cells need ___________ to optimize the exchange of material through the plasma membrane
a high surface area to volume ratio
Separates internal cell environment from external cell environment
plasma membrane
What is the plasma membrane made up of?
phospholipids
What are phospholipids in regards to charge?
amphipathic
How does the cell membrane create a bilayer?
the hydrophilic heads facing towards the environment and the nonpolar tails facing inward
A model to describe the structure of cell membranes
fluid mosaic model
Why do they call it a fluid mosaic model
cell membrane is held together by weak, hydrophobic interactions that can make it move and shift and is comprised of many macro molecules
How does cholesterol help maintain fluidity?
reduces movement in high temperatures and reduces tight packing in low temperatures
What are the two major categories of proteins in the membrane?
integral proteins and peripheral protein proteins
Proteins that are embedded into the lipid by layer in our determined by R groups
integral proteins
What makes up an integral protein?
interior is hydrophilic and exposed to the side of salt and the channel is hydrophobic
Proteins that are not embedded into the lipid bilayer and are bonded loosely to the surface
peripheral protein proteins
Purpose of membrane carbohydrates
cell to cell recognition
What are the two types of membrane carbohydrates?
glycolipids and glycoproteins
The ability of membranes to regulate the substances that enter and exit the cell
selective permeability
How can selective permeability occur?
non-polar hydrophobic tails of phospholipids
What substances can easily pass across the membrane?
small, nonpolar, hydrophobic molecules
What molecules is it hard to pass through the cell membrane or need protein assistance?
hydrophilic, polar molecules, large molecules, and ions
What are the function of cell walls?
provide structural boundary permeability barrier for some substances protection from osmatic lysis
What does a cell wall contain?
plasmaodesmata
What are the two types of transport across a membrane?
passive and active
Transport of a molecule that does not require energy from the cell because it is a solute moving within its electrochemical gradient
passive transport
Three types of passive transport
diffusion, osmosis, and facilitated diffusion
Spontaneous process, resulting from the constant motion of molecules
diffusion
What happens in diffusion?
substances move from high to low concentration down the concentration gradient to achieve dynamic equilibrium
The diffusion of water down its concentration gradient across a selectively permeable membrane
osmosis
Diffusion of molecules through the membrane via channel or carrier proteins; does not require energy
Facilitated diffusion
Form a pore/channel in the membrane and have gates that can open in response to stimuli
channel proteins
Specialized channel proteins for water water
aquaphorins
Alternate between two confirmations and help move large polar molecules (glucose, amino acids, and nucleosides)
carrier proteins
Transport of a molecule that requires energy because it is moving against its concentration ingredient
active transport
What does active transport require?
ATP
What are the types of active transport?
pumps, transport, exocytosis endocytosis
How does ATP transport its energy?
transfers, terminal phosphate group to transport protein to help move the substance
Maintain membrane potential
pumps
Unequal concentrations of ions across the membrane and results to electrical charge
membrane potential
Proteins that generate voltage across membranes, which can be used as an energy source for cellular processes
electrogenic pump
How animal cells will regulate their relative concentrations of NA and K
sodium potassium pump
How does the sodium potassium pump work?
three NA pumped out of the cell and two K pumped into the cell
Integral membrane protein that builds up a proton gradient against the membrane by pumping hydrogen out of the cell
proton pump
Coupling of favorable movement of one substance with an unfavorable movement of another substance
transport
Example of co-transport
sucrose can only travel against its concentration ingredient if hydrogen is diffusing down the gradient
Two ways large substances are moved in and out of the cell
endocytosis and exocytosis
The secretion of molecules via vesicles that fuse to the plasma membrane by forming a bilayer
exocytosis
The uptake of molecules from vesicles fused to the plasma membrane
endocytosis
Type types of endocytosis
phagocytosis, pinocytosis and receptor-mediated
When a cell engulf particles to later be digested by lysosomes
phagocytosis
How does phagocytosis take place?
cell surrounds particle with pseudopodia and packages particles into a food vacuole to be used with a lysosome
Nonspecific uptake of extracellular fluid containing dissolved material materials
pinocytosis
Specific uptake of molecules via solute binding to receptors on the plasma membrane
receptor mediated endocytosis
the basic structural and functional units of every organism
cell
what do all cells have
plasma membrane, cytosol, chromosomes, ribosomes
what are the 2 types of cells
prokaryotic and eukaryotic
what do prokaryotic cells have
bacteria, domains, archea
DNA in nucleoid
small in size compared to eukaryotes
lack membrane bound organelles
unicellular
what do eukaryotes have
protists, fungi, plants, animals
DNA in nucleus
contain membrane bound organelles
compartmentalize cellular functions
membrane bound structures in eukaryotes
organelles
organelles and subcellular components that interact to modify, packagem and transport polysaccharides, lipids, and proteins
endomembrane system
organelles in endomembrane system
nuclear envelope, ER, golgi, lysosomes, vacuoles, vesticles, plasma membrane
convert energy to forms that the cell can use for work
energy organelles
organelles that are energy organelles
mitochondira, and chloroplasts
different metabolic processes happening in different locations; increase surface area and prevent interfering reactions from occuring in the same location
compartmentalization
can prokaryotes have compartmentalization
yes
what does plant cells have that are unique to the cell
cell wall, chlorplasts, plasmodesmata, central vacuole
what do animal cells have that are unique to the cell
lysosomes, centrosomes, flagella
surrounds the nucleus and all of its components
nuclear envelope
surrounded by nuclear envelope, double membrane, has pores that regulate entry and exit
nucleus
dense region where ribosomal RNA (rRNA) is synthesized
nucleolus
_____ is combined with _____ to form large and small subunits of ribosomes
rRNA; proteins
ribosomes translate messages found on mRNA into the
primary structure of poly peptides
comprised of RNA and protein
ribosomes
function of ribosomes
synthesize proteins
where can ribosomes be found
cytosol and ER
network of membranous sacs and tubules
ER
functions of ER
mechanical support by maintaining cell shape and transport within the cell
2 types of ER
rough and smooth
function of rough ER
contains ribosomes bound to ER membrane
compartmentalizes protein synthesis
function of smooth ER
synthesis of lipids and detoxification of the cell
membranous sacs in ER and golgi
cisternae
function of golgi
recieves transport vesticles from Er, modifies/sorts materials, adds molecular tags, packages new materials
2 faces of golgi
cis face and trans face
recieves vesticles from ER
cis face
sends vesticles back out of golgi into the cytosol to other locations or to the plasma membrane
trans face
membranous sac with hydrolytic enzymes in animal cells
lysosomes
function of lysosmes
digests/eats macromolecules, autophage, plays a role in apoptosis
lysosomes can recycle their own cells orginal matrix and organelles that are not functioning properly
autophagy
steps of autophagy
membrane formed around bad organelle —> fuses with lysosome —> enzymes break down the organelle and components are recycled
membrane bound metabolic compartments that detoxifies the cell
peroxisomes
how do peroxisomes detoxify the cell
produce H2o2 to detoxify and then enzyme breaks it down to water and oxygen
stem from ER to golgi and involved transport
The transport vesicles
aminal cell vacuoles
small in size, store materials, assist in endocytosis and exocytosis
plant cell vacuoles
one large central vacuole, stores nutrients and water for turgor pressure, function like lysosomes
site of cellular respiration and has a double membrane; location for krebs cycle
mitochondria
describe membranes of mitochondria
outer membrane is smooth and inner membrane has folds called cristae, which increase surface area for ATP production.
space between inner and outer membrane in mitochondria
intermembrane
enclosed by inner membrane
mitochondrian matrix
number of mitochondria correlates with
metabolic activity
specialized organleed for plants and algae that is the site of photosynthesis; contains chrolophyll
chloroplast