Cannabis and Appetite

Flashcards about Cannabis and Appetite

What effect does THC have on milkshake consumption?

THC increases milkshake consumption

What effect do CB1 agonists have on reward and leptin secretion?

CB1 agonists increase reward and decrease leptin secretion.

What are some conditions where Cachexia is a symptom?

Cancer, AIDS, and anorexia

What have FAAH inhibitors shown in animal models?

FAAH inhibitors show promise by increasing endogenous AEA levels and having a more targeted effect.

What happens when CB1 receptors are deleted in relation to THC and leptin?

Deletion of CB1 receptors blocks the effects of both THC and leptin.

What is the role of Cholecystokinin in appetite?

Cholecystokinin is a satiety signal that decreases CB1 expression.

What is the role of Ghrelin in appetite?

Ghrelin stimulates feeding and maintains CB1 expression, which is increased by CB1 agonists.

How do highly palatable foods affect eating behavior?

Highly palatable foods induce a reward response that is CB1-dependent.

How does the body react to pleasure eating in terms of CB1 expression and endocannabinoid response?

Pleasure eating reduces CB1 expression, causing a negative feedback loop that decreases response to endocannabinoids. Fasting increases endocannabinoid levels.

How is endocannabinoid dysregulation related to obesity?

There is a correlation between obesity and endocannabinoid dysregulation, with overproduced endocannabinoids and overexpressed CB1 receptors.

Why was Rimonabant withdrawn from the market?

Rimonabant was withdrawn from the market due to psychiatric effects.

What is THCV and what is its function?

THCV, or Tetrahydrocannabivarin, is a pure CB1 antagonist.

What is Cannabinol and how does it affect feeding?

Cannabinol is a breakdown product of THC, a partial agonist, less psychoactive than THC and increases feeding in rats.

How does CBD impact feeding behavior?

CBD yields mixed results, and might reduce feeding if administered shortly before food.