Rh genes and Antibodies

R = Presence of…

D

r = Absence of

D

1 or ‘ = Presence of

C

2 or “ = Presence of

E

0 = Presence of

c + e

Z or y = Presence of

C + E

R⁰ (Weiner) = ____ (Fisher-race)

cDe

R¹ (Weiner) = ____ (Fisher-race) *one of the most common types

CDe

R² (Weiner) = ____ (Fisher-race)

cDE

R^z (Weiner) = ____ (Fisher-race)

CDE

r (Weiner) = ____ (Fisher-race) *One of the most common types

cde

r’ (Weiner) = ____ (Fisher-race)

Cde

r” (Weiner) = ____ (Fisher-race)

cdE

r^y (Weiner) = ____ (Fisher-race)

CdE

Naturally occurring Antibodies are… (PALLM)

P₁

ABO

Lewis

Lu^a

MN

Clinically Significant Antibodies are… (DARKKS)

Duffy

ABO

Rh

Kell

Kidd

SsU

Warm Antibodies are… (DuRKK)

Duffy

Rh

Kell

Kidd

Cold Antibodies are…(MNP)

M

N

P₁

Antibodies that usually ONLY react in AHG (not detected on IS) (KDK)

Kell

Duffy

Kidd

Antibodies that can react in ANY phase of testing (1)

Lewis

Detection is enhanced by enzyme treatment of test cells (KLR)

Kidd

Lewis

Rh

No detection with enzyme treatment of test cells (DMN)

Duffy

M

N

Enhanced with acidification (1)

M

Antibodies that show dosage (RMDK)

Rh other than D

MNS

Duffy

Kidd

Antibodies that bind complement (LIK)

Lewis

I

Kidd

Cause in vitro hemolysis (VALKP)

Vell

ABO

Lewis

Kidd

P₁ (some)

Labile in vivo and in vitro

Kidd

Common cause of anamnestic response (delayed transfusion reaction)

Kidd

Associated with paroxysmal nocturnal hemoglobinuria

Anti-P₁