Intestinal Polyps and Neoplasia

Hamartoma

A benign tumor-like growth that is composed of mature tissue matching site of growth

>5 years old , rectal bleeding , and polyp with cystic spaces

juvenile polyposis syndrome.

Juvenile polyposis syndrome gene

SMAD4 or BMPR1A

Juvenile Polyposis

Peutz Jeghers Syndrome

Peutz Jeghers Syndrome

autosomal dominant STK11 mutation resulting in brown macules and hemartomas

Smooth muscle arborizing polyp =

Peutz Jeghers Polyp

Hyperplastic Polyp- More common on the left side of the (distal colon)

Sessile Serrated Polyp - Pre malignant and in the proximal colon (right side)

Adenoma

Most important risk factor for adenoma malignancy

Size

Adenoma to Carcinoma Sequence gene mutation

APC

Microsatellite instability & MMR Mutation

Lynch Syndrome

Familial Adenomatous Polyposis

Neuroendocrine Tumor = Salt and Pepper Chromatin