Cellular Regulation: Lymphoma System Disorder

Vocabulary flashcards focusing on definitions, diagnostic procedures, classic findings, safety complications, and categories of Lymphoma based on the lecture transcript.

Lymphoma

A cancer of the lymphatic/immune system caused by abnormal proliferation of lymphocytes, leading to uncontrolled accumulation of malignant lymphocytes in lymph nodes and lymphatic tissues.

Hodgkin Lymphoma

A major category of lymphoma that often begins in a lymph-node region, spreads in a predictable pattern, and is characterized by the presence of Reed-Sternberg cells.

Non-Hodgkin Lymphoma

A major category of lymphoma characterized by variable patterns of spread, an absence of Reed-Sternberg cells, and a prognosis that varies widely by subtype.

Reed-Sternberg Cells

Characteristic cells present in Hodgkin lymphoma that are absent in non-Hodgkin lymphoma.

B Symptoms

A clinical triad consisting of fever, drenching night sweats, and unexplained weight loss.

Lymph-Node Biopsy

The key diagnostic procedure that establishes the definitive diagnosis and identifies the subtype of lymphoma.

Excisional Biopsy

The preferred method of lymph-node biopsy when feasible because it allows evaluation of the lymph node's architecture.

Superior Vena Cava Syndrome

A major safety concern occurring when a large tumor or lymph-node mass compresses the superior vena cava, resulting in facial swelling, neck swelling, upper-extremity edema, distended neck/chest veins, cough, dyspnea, and headache.

Tumor Lysis Syndrome

An emergency condition occurring after effective cancer treatment causes rapid destruction of tumor cells, characterized by elevated potassium, elevated uric acid, elevated phosphate, and altered calcium levels, leading to potential dysrhythmias, seizures, and acute kidney injury.

Febrile Neutropenia

An oncology emergency where a patient with significant neutropenia develops a fever, requiring immediate notification of the healthcare team.

Lactate Dehydrogenase (LDH)

A laboratory test that may be elevated in lymphoma and can correlate with disease activity or tumor burden.

Complete Blood Count (CBC)

A laboratory test that provides useful information such as anemia or other blood-cell abnormalities in lymphoma, but does not establish the diagnosis or subtype.

Active Surveillance

A management strategy used initially for some slow-growing lymphomas rather than immediate active treatment.

Classic Assessment Findings of Lymphoma

Clinical manifestations including painless lymph-node enlargement, fever, drenching night sweats, unexplained weight loss, fatigue, pruritus, decreased appetite, and hepatosplenomegaly.