[MEDICINAL CHEMISTRY] Antiscabies & Antipedicular Agents

b. Scabicides

Agents that control the mite Sacroptes scabei

a. Pediculicides
b. Scabicides
c. Anthelmintics
d. Miticides

a. Sarcoptes scabiei

Scabicides are agents that control the mite _______

a. Sarcoptes scabiei

b. Pediculus humanus

c. Demodex folliculorum

d. Dermatophagoides pteronyssinus

a. Benzyl Benzoate

From Peru Balsam, also from benzyl OH + benzoyl chloride

a. Benzyl Benzoate
b. Benzyl Alcohol
c. Benzocaine
d. Benzoyl Peroxide

c. Benzyl Benzoate

Topical scabicide

a. Lindane

b. Permethrin

c. Benzyl Benzoate

d. Crotamiton

b. Benzyl Benzoate

Immediate relief from itching

a. Crotamiton
b. Benzyl Benzoate
c. Sulfur
d. Calamine

b. Benzyl Benzoate

Colorless liquid ester with faint aromatic odor

a. Benzyl Alcohol
b. Benzyl Benzoate
c. Ethyl Acetate
d. Methyl Salicylate

b. Antipruritic

Crotamiton is used as _____

a. Antifungal
b. Antipruritic
c. Antibacterial
d. Antiviral

c. Crotamiton

Antipruritic with local anesthetic action

a. Permethrin
b. Lindane
c. Crotamiton
d. Sulfur

a. Crotamiton

Available as a 10% lotion or cream for the treatment of scabies.

a. Crotamiton
b. Benzyl benzoate
c. Ivermectin
d. Malathion

c. Crotamiton

Colorless, oily liquid used as 10% lotion/cream for scabies with antipruritic (local anesthetic action).

a. Permethrin
b. Lindane
c. Crotamiton
d. Sulfur

b. Pediculocides

Used to eliminate head, body, and crab lice

a. Scabicides
b. Pediculocides
c. Anthelmintics
d. Miticides

c. Permethrin

Exerts a lethal action against lice, ticks, mites, and fleas.

a. Crotamiton
b. Lindane
c. Permethrin
d. Malathion

b. Permethrin

MOA: Acts on nerve cell membranes → disrupts Na⁺ channel conductance = paralysis.

a. Ivermectin
b. Permethrin
c. Benzyl benzoate
d. Sulfur

b. Permethrin

Available as a 1% lotion for the treatment of lice.

a. Crotamiton
b. Permethrin
c. Lindane
d. Pyrethrin

a. 1%

Permethrin is available at _____% concentration of lotion for the treatment of lice.

a. 1%
b. 2%
c. 5%
d. 10%

c. 5%

Permethrin is available at _____% concentration of cream for the treatment of scabies.

a. 1%
b. 2.5%
c. 5%
d. 10%

a. Pruritus

Side effect of Permethrin is:

a. Pruritus
b. Burning sensation
c. Rash
d. All of the above

c. Lindane

Kwell®

a. Permethrin
b. Crotamiton
c. Lindane
d. Ivermectin

c. Lindane

Scaben®

a. Permethrin
b. Crotamiton
c. Lindane
d. Ivermectin

c. Lindane

Kwildane®

a. Permethrin
b. Crotamiton
c. Lindane
d. Ivermectin

c. Lindane

• Direct contact poison

• Fumigant effect

• Stomach poison

Are 3-fold actions of which drug?

a. Malathion
b. Pyrethrin
c. Lindane
d. Sulfur

c. Lindane

Side effect: Neurotoxicity.

a. Crotamiton
b. Permethrin
c. Lindane
d. Sulfur

c. Pyrethrin

Obtained from chrysanthemum plants

a. Lindane
b. Permethrin
c. Pyrethrin
d. Crotamiton

a. Chrysanthemum plants

Pyrethrin is obtained from ______

a. Chrysanthemum plants
b. Tobacco plants
c. Neem trees
d. Eucalyptus trees

c. Pyrethrin

MOA involves nerve poisoning

a. Lindane
b. Permethrin
c. Pyrethrin
d. Crotamiton

a. Piperonyl butoxide

Enhances the pediculicide effects of pyrethrins.

a. Piperonyl butoxide
b. Malathion
c. Benzyl benzoate
d. Ivermectin