HIV Meds

What is the drug class of bictegravir?`

Integrase Strand Transfer Inhibitor (INSTI)

What is the drug class of dolutegravir?

Integrase Strand Transfer Inhibitor (INSTI)

What is the drug class of raltegravir?

Integrase Strand Transfer Inhibitor (INSTI)

What is the drug class of elvitegravir?

Integrase Strand Transfer Inhibitor (INSTI)

What is the common suffix for INSTIs?

gravir

Why are INSTIs often included in first-line HIV regimens?

They have a high barrier to resistance.

Which INSTI must be spaced apart from antacids, oral iron, oral calcium, sucralfate, and buffered medications?

Dolutegravir

Which INSTIs should be taken with food?

Elvitegravir and cabotegravir

What are common side effects of INSTIs?

Nausea, diarrhea, abdominal pain, headache, insomnia, dizziness, somnolence, fatigue, abnormal dreams

Which serious skin reaction can occur with INSTIs?

Stevens-Johnson Syndrome (SJS)

Which INSTI is associated with hepatotoxicity?

Dolutegravir

Which INSTI can cause myopathy or rhabdomyolysis?

Raltegravir

What psychiatric adverse effects can INSTIs cause?

Depression or suicidal ideation

What body effect may occur with INSTIs?

Redistribution of body fat

What is the drug class of atazanavir?

Protease Inhibitor (PI)

What is the drug class of darunavir?

Protease Inhibitor (PI)

What is the drug class of fosamprenavir

Protease Inhibitor (PI)

What is the drug class of indinavir?

Protease Inhibitor (PI)

What is the drug class of lopinavir/ritonavir?

Protease Inhibitor (PI)

What is the drug class of nelfinavir?

Protease Inhibitor (PI)

What is the drug class of ritonavir?

Protease Inhibitor (PI)

What is the drug class of saquinavir?

Protease Inhibitor (PI)

What is the drug class of tipranavir

Protease Inhibitor (PI)

What is the common suffix for Protease Inhibitors?

-navir

How are most Protease Inhibitors administered?

Oral, usually with food; some exceptions like lopinavir/ritonavir tablets and fosamprenavir tablets

What are common side effects of Protease Inhibitors?

Nausea, vomiting, diarrhea, headache, abdominal pain, rash, dyslipidemia

What are class-wide serious warnings for Protease Inhibitors?

Stevens-Johnson syndrome, lipodystrophy, hepatotoxicity, cardiac conduction abnormalities, hemophilia exacerbation

Atazanavir side effects

• Hyperbilirubinemia, peripheral neurologic symptoms

Fosamprenavir, tipranavir, darunavir aleergy

Sulfa - use caution

What is the drug class of delavirdine

Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs)

What is the drug class of efavirenz

Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs)

What is the drug class of etravirine

Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs)

What is the drug class of nevirapine

Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs)

What is the drug class of rilpivirine

Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs)

What is the drug class of doravirine

Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs)

What is the common suffix for NNRTIs?

Many end in -ine

What should NNRTIs typically be combined with for treatment?

Historically with 2 NRTIs; now often given with an INSTI in 2-drug regimens

Which NNRTI should be taken on an empty stomach?

Efavirenz

Which NNRTI should be taken with a meal?

Rilpivirine

What are common side effects of NNRTIs?

Nausea, vomiting, diarrhea, rash, dyslipidemia, QT prolongation, abnormal dreams

Which NNRTI is associated with depressive disorders?

Rilpivirine

What are serious adverse reactions or warnings for NNRTIs?

Stevens-Johnson syndrome (SJS) and severe skin reactions, immune reconstitution inflammatory syndrome (IRIS), hepatotoxicity, serious depression or suicidal ideation, increased cholesterol and triglycerides, lipodystrophy

Which NNRTI has a specific hepatotoxicity warning related to CD4 count and gender?

Nevirapine — risk increases in women with CD4 > 250 and men with CD4 > 400

What is the drug class of Abacavir

Nucleoside Reverse Transcriptase Inhibitors (NRTIs)

What is the drug class of Didanosine

Nucleoside Reverse Transcriptase Inhibitors (NRTIs)

What is the drug class of Emtricitabine

Nucleoside Reverse Transcriptase Inhibitors (NRTIs)

What is the drug class of Lamivudine

Nucleoside Reverse Transcriptase Inhibitors (NRTIs)

What is the drug class of Stavudine

Nucleoside Reverse Transcriptase Inhibitors (NRTIs)

What is the drug class of Tenofovir

alafenamide (TAF)

Nucleoside Reverse Transcriptase Inhibitors (NRTIs)

What is the drug class of Tenofovir disoproxil

fumarate

Nucleoside Reverse Transcriptase Inhibitors (NRTIs)

What is the drug class of Zidovudine

Nucleoside Reverse Transcriptase Inhibitors (NRTIs)

What is the common suffix for NRTIs?

Many end in -ine

What are common side effects of NRTIs?

Nausea, vomiting, headache, fatigue, peripheral neuropathy

What serious metabolic or systemic adverse effects are associated with NRTIs?

Lactic acidosis, hepatotoxicity

Which NRTI is specifically associated with anemia and increased MCV (macrocytic anemia)?

Zidovudine

Which NRTI requires HLA-B*5701 testing before initiation due to hypersensitivity risk?

Abacavir

What is the difference between TDF (tenofovir disoproxil fumarate) and TAF (tenofovir alafenamide)?

TAF is a next-generation prodrug of tenofovir diphosphate (TFV-DP), considered more effective and with less risk of renal and bone toxicities compared to TDF

What is the generic name of Triumeq?

Dolutegravir/abacavir/lamivudine

What is the brand name of dolutegravir/abacavir/lamivudine?

Triumeq

What is the drug class of Triumeq?

INSTI (dolutegravir) plus 2 NRTIs (abacavir + lamivudine)

What is the generic name of Genvoya?

Elvitegravir/cobicistat/tenofovir alafenamide (TAF)/emtricitabine

What is the brand name of elvitegravir/cobicistat/TAF/emtricitabine?

Genvoya

What is the drug class of Genvoya?

INSTI (elvitegravir) plus CYP450 inhibitor (cobicistat) plus 2 NRTIs (TAF + emtricitabine)

What is the generic name of Biktarvy?

Bictegravir/emtricitabine/TAF

What is the brand name of bictegravir/emtricitabine/TAF?

Biktarvy

What is the drug class of Biktarvy?

INSTI (bictegravir) plus 2 NRTIs (emtricitabine + TAF)

What is the generic name of Stribild?

Elvitegravir/cobicistat/tenofovir disoproxil fumarate (TDF)/emtricitabine

What is the brand name of elvitegravir/cobicistat/TDF/emtricitabine?

Stribild

What is the drug class of Stribild?

: INSTI (elvitegravir) plus CYP450 inhibitor (cobicistat) plus 2 NRTIs (TDF + emtricitabine)

What is the generic name of Symtuza?

Darunavir/cobicistat/emtricitabine/TAF

Q

What is the brand name of darunavir/cobicistat/emtricitabine/TAF?

Symtuza

\What is the drug class of Symtuza?

PI (darunavir) plus CYP450 inhibitor (cobicistat) plus 2 NRTIs (emtricitabine + TAF)

What is the generic name of Atripla?

Efavirenz/emtricitabine/TDF

What is the brand name of efavirenz/emtricitabine/TDF?

Atripla

What is the drug class of Atripla?

NNRTI (efavirenz) plus 2 NRTIs (emtricitabine + TDF)

What is the generic name of Odefsey?

Rilpivirine/emtricitabine/TAF

What is the brand name of rilpivirine/emtricitabine/TAF?

Odefsey

What is the drug class of Odefsey?

NNRTI (rilpivirine) plus 2 NRTIs (emtricitabine + TAF

What is the generic name of Dovato?

Dolutegravir/lamivudin

What is the brand name of dolutegravir/lamivudine?

Dovato

What is the drug class of Dovato?

INSTI (dolutegravir) plus 1 NRTI (lamivudine)

What is the generic name of Juluca?

Dolutegravir/rilpivirine

What is the brand name of dolutegravir/rilpivirine?

Juluca

What is the drug class of Juluca?

INSTI (dolutegravir) plus 1 NNRTI (rilpivirine)

What is the generic name of Cabenuva (long-acting IM injection)?

Cabotegravir/rilpivirine

What is the brand name of cabotegravir/rilpivirine?

Cabenuva

What is the drug class of Cabenuva?

INSTI (cabotegravir) plus 1 NNRTI (rilpivirine)

What is the generic name of Descovy [PrEP]?

Emtricitabine/TAF

What is the brand name of emtricitabine/TAF?

Descovy

What is the drug class of Descovy [PrEP]?

2 NRTIs

What is the generic name of Truvada [PrEP]?

Emtricitabine/TDF

What is the brand name of emtricitabine/TDF?

Truvada

What is the drug class of Truvada [PrEP]?

2 NRTIs

What is the only CCR5 co receptor antagonist

Maraviroc

What is the brand name of Maraviroc 

Selzentry

What is the generic or Selzentry

Maraviroc

What type of HIV-1 is Maraviroc effective against?

Only CCR5-tropic HIV-1

What is the drug class of Maraviroc 

CCR5 Co-Receptor Antagonist

In what types of patients can Maraviroc be used?

In treatment-experienced or treatment-naïve patients (with CCR5-tropic HIV-1)

What enzyme metabolizes Maraviroc?

CYP3A4 (substrate)