Glycogenesis and Glycogenolysis

Glycogenesis

1. Glucose 6 phosphate → Glucose 1 phosphate

phosphoglucomutase

Glycogenesis

2. synthesis of UDP glucose

UDP glucose pyrophosphorylase

Glycogenesis

3. synthesis of initiating primer

Glycogenin

Glycogenesis

4. chain elongation

glycogen synthase

Glycogenesis

5. formation of branches (create 1,6; extend 1,4)

4:6 transferase

Glycogenolysis

1. shortening of glycosidic chain

glucose phosphorylase

Glycogenolysis

2. debranching (moves 3 resides)

1:4 transferase

Glycogenolysis

3. debranching (removes 1 glucose)

1:6 glucosidase

Glycogenolysis

4. glucose 1 phosphate → glucose 6 phosphate

phosphoglucomutase

Glycogenolysis

• _____ is the four glucosyl unit stump

• initiates the action of a debranching enzyme

limit dextrin

______ and _______ are hormonally regulated by insulin, glucagon and epinephrine (aka adrenaline)

Glycogen phosphorylase, glycogen synthase