mechanisms of druh actions

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Last updated 3:54 AM on 9/22/26
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15 Terms

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ligand

compound that binds to receptor (can be NT)

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agonist

ligand/drug activates receptor

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antagonist

ligand/drug that blocks receptor

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affinity

how well drug binds with receptor

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efficacy

how well drug activates receptor

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competitive effects

ligand binding to a receptor on same site as another

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non-competitive effects

ligand binding on diff site from ligand

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tolerance

decrease in response to drug after repeated exposure

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metabolic tolerance

body clears drug faster (breaking down)

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functional tolerance

NS adapts to drugs presence

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antipsychotics/neuroleptics

typical = D2 receptor antagonists

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antidepressants

3 categories (afferent)

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3 categories of AD

monoamine oxisdase inhibitor, tricyclics (clock NET/SERT), SSRI

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Anxiolytics

older ones (opiates/alcohol/barbiturates) benzodiazepines (enhance GABA-A

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alcohol

activates GABA-A, increase DA