retroviruses - virology exam

retroviruses

can become a permanent part of a cell

types of retrovirsues

hiv, htlv-1, herv

types of hiv

hiv-1 (siv - cpz), hiv-2 (siv - sm)

location + natural host of hiv-1

world wide, chimpanzee

location + natural host of hiv-2

africa, sooty mangabey (monkey)

target cells of hiv

cd4+ cells, receptor cells

location of hiv

blood, lymphoid tissue, bodily fluids (breast milk, semen), bone marrow

transmission of hiv

blood and blood products, sexual, breast milk

disease of hiv

never fully goes away, flu like symptoms, death of cd4+ cells

pathogenesis of hiv

primary infection, acute, clinical latency, symptoms, disease, death

what can change the pathogenesis of hiv

mhc types - makes different cd8+ t cell responses

immune response to hiv

delay onset, decrease transmission

is there immune resistance with hiv

yes - mutations, spike proteins

treatment for hiv

attachment, fusion, reverse transcriptase, integrase, and protease inhibitors. ART therapy

is there a vaccine for HIV

no

pathogenesis of htlv-1

cancer

transmission of htlv-1

blood and blood products, sexual, breast milk

htlv-1 stands for

human t-cell leukemia virus