Blood Bank Exam 1: Rh Blood Group System

the Rh antigen is this kind of antigen

protein

the Rh antigen is names after this

Rhesus monkey

the D antigen is this kind

multipass

D is the most important _____________ antigen

immunogenic

what is the immunogenicity of these antigens in order of most to least

e

c

C

E

Weiner theory of Rh inheritance

EVERYTHING INHERITED TOGETHER

single gene at Rh locus

gene product is agglutinogen (haplotype)

agglutinogen is composed of factors (epitope)

what fischer race haplotypes are most common in white people

DCe

dce

what fischer race haplotypes are most common in black people

Dce

dce

what fischer race haplotypes are most common in asian people

DCe

DcE

in weiner, capitol R correlates with

capital D

In weiner, lower case r correlates with

lower case d

R1 is

DCe

R2 is

DcE

Rz is

DCE

R0 is

Dce

r is

dce

r' is

dCe

r'' is

dcE

ry is

dCE

how are Rh genes actually inherited

triplet theory

D/d are connected

E/e and C/c are connected

RHD and RHCE gene are on chromosome ______________ and are _______________

chromosome 1

polymorphic

RHAG gene is on chromosome ____ and is _______________

chromosome 6

monomorphic

when white people are Rh negative it is due to this

a deletion in the Rh gene

when black people are Rh negative it is due to this

insertion in the Rh gene changes its function

what are the three possible ways for a person to be D negative

gene deletion

insertion creates a pseudogene

hybrid gene

the RhD vestibule is this kind of protein

transport protein. the outside is more important of the inside

in order to have the RHAG gene we must have

d and e (big or little)

no RhAG means no

Rh antigens

RhAG may also play an important role in the integrity of this cell structure

the cytoskeleton

when the cytoskeleton is weakened we see these RBC shapes

spherocytes

stomatocytes

Anti-D is the _____________ of antibodies

most studied (rock star)

Anti-D is

IgG

why is Rh important

implicated in HDFN and HTR