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activation energy
energy necessary for reactions to occur
active site
enzyme’s specific region to which the substrate binds
active transport
method of transporting material that requires energy
adenosine diphosphate (ADP)
nucleotide with two phosphates formed when ATP gives up a phosphate
adenosine triphosphate (ATP)
nucleotide with three phosphate groups that is the primary energy currency of the cell
allosteric inhibitor
inhibition by a binding event at a site different from the active site, which induces a conformational change and reduces the enzyme’s affinity for its substrate
amphipathic
molecule possessing a polar or charged area and a nonpolar or uncharged area capable of interacting with both hydrophilic and hydrophobic environments
aquaporin
channel protein that allows water through the membrane at a very high rate
carrier protein (transporter)
membrane protein that moves a substance across the plasma membrane by changing its own shape
channel protein
membrane protein that allows a substance to pass through its hollow core across the plasma membrane
coenzyme
small organic molecule, such as a vitamin or its derivative, which is required to enhance an enzyme’s activity
cofactor
inorganic ion, such as iron and magnesium ions, required for optimal enzyme activity regulation
competitive inhibition
type of inhibition in which the inhibitor competes with the substrate molecule by binding to the enzyme’s active site
concentration gradient
area of high concentration adjacent to an area of low concentration
diffusion
passive transport process of low-molecular weight material according to its concentration gradient
endergonic reaction
a chemical reaction that absorbs energy rather than releasing energy on balance
endocytosis
type of active transport that moves substances, including fluids and particles, into a cell
exergonic reaction
a reaction that releases free energy
exocytosis
process of passing bulk material out of a cell
facilitated diffusion
process by which material moves down a concentration gradient (from high to low concentration) using integral membrane proteins
feedback inhibition
a product’s effect of a reaction sequence to decrease its further production by inhibiting the first enzyme’s activity in the pathway that produces it
fluid mosaic model
describes the plasma membrane’s structure as a mosaic of components including phospholipids, cholesterol, proteins, glycoproteins, and glycolipids (sugar chains attached to proteins or lipids, respectively), resulting in a fluid character (fluidity)
glycolipid
combination of carbohydrates and lipids
glycoprotein
combination of carbohydrates and proteins
hydrophilic
molecule with the ability to bond with water; “water-loving”
hydrophobic
molecule that does not have the ability to bond with water; “water-hating”
hypertonic
situation in which extracellular fluid has a higher osmolarity than the fluid inside the cell, resulting in water moving out of the cell
hypotonic
situation in which extracellular fluid has a lower osmolarity than the fluid inside the cell, resulting in water moving into the cell
integral protein
protein integrated into the membrane structure that interacts extensively with the membrane lipids’ hydrocarbon chains and often spans the membrane
ion channel
protein that allows specific ions to diffuse across the membrane down their concentration gradient
isotonic
situation in which the extracellular fluid has the same osmolarity as the fluid inside the cell, resulting in no net water movement into or out of the cell
osmolarity
total amount of substances dissolved in a specific amount of solution
osmosis
transport of water through a semipermeable membrane according to the water’s concentration gradient across the membrane that results from the presence of solute that cannot pass through the membrane
passive transport
method of transporting material through a membrane that does not require energy
peripheral protein
protein at the plasma membrane’s surface either on its exterior or interior side
phagocytosis
process by which a cell takes in relatively large particles (type of endocytosis)
primary active transport
active transport that moves ions or small molecules across a membrane using ATP to drive substrates up their concentration gradient
pump
active transport mechanism that works against electrochemical gradients
secondary active transport
movement of a solute up its concentration gradient, powered by an energy source other than ATP
selectively permeable
membrane characteristic that allows some substances through
solute
substance dissolved in a liquid to form a solution
substrate
molecule on which the enzyme acts
tonicity
amount of impermeable solute in a solution