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What are the three defined steps in tumor progression to malignancy?
DNA mutation, angiogenesis, and metastasis.
How do DNA mutations contribute to cancer progression?
Mutations in tumor suppressor genes or proto-oncogenes lead to uncontrolled cell division.
What role does angiogenesis play in tumor progression?
It provides the tumor with increased access to nutrients and oxygen via new blood vessels.
What is metastasis in tumor progression?
The spread of cancer cells to other parts of the body due to loss of anchorage dependence.