Introduction to the TCA Cycle

These flashcards cover key concepts related to the TCA Cycle, its functions, regulation, and essential metabolic connections.

What are some alternate names for the TCA Cycle?

The TCA Cycle is also known as the Tricarboxylic Acid Cycle, the Citric Acid Cycle, and the Krebs Cycle.

Where does the TCA Cycle operate within the cell?

The TCA Cycle operates in the mitochondrial matrix.

What is the main function of the TCA Cycle?

The main functions of the TCA cycle include providing energy through catabolic reactions and supplying metabolites for biosynthetic pathways.

What key reduced nucleotides are generated by the TCA Cycle?

The TCA Cycle generates NADH and FADH2, which are used to produce ATP by oxidative phosphorylation.

What role does Acetyl CoA play in the TCA Cycle?

Acetyl CoA enters the TCA Cycle for oxidation and generates reduced coenzymes while providing free energy for ATP synthesis.

What are the three key regulatory enzymes of the TCA Cycle?

The three key regulatory enzymes are citrate synthase, isocitrate dehydrogenase, and alpha-ketoglutarate dehydrogenase.

What happens to the carbon atoms in Acetyl CoA during the TCA Cycle?

For each molecule of Acetyl CoA that enters the TCA Cycle, 2 carbons are released as CO2 by the end of the cycle.

What is the net energy yield of one Acetyl CoA in the TCA Cycle?

The net energy yield from one molecule of Acetyl CoA is 12 ATP: 9 from NADH and 2 from FADH2, and 1 GTP.

What is the purpose of anaplerotic reactions in the TCA Cycle?

Anaplerotic reactions help replenish TCA Cycle intermediates, maintaining its activity and function.

What are inborn errors of metabolism in relation to the TCA Cycle?

Inborn errors of metabolism refer to deficiencies in converting pyruvate to oxaloacetate or acetyl CoA, leading to severe metabolic disturbance.