Inhibition of Protein Synthesis and Translation Comparison

Vocabulary flashcards covering inhibitors of protein synthesis, RNA synthesis, and key structural/functional differences in translation between bacteria and eukaryotes.

Tetracycline

Inhibits the binding of AA - + RNA to the ribosomes.

Streptomy escin

Inhibits the initiation of translation.

Neomyan

Inhibits the interaction blu mRNA and tRNA.

Chloramphenicol

Inhibits the action of enzyme peptidyl transferase and the formation of peptide bonds.

Erythromysin

Inihbits the translocation of ribosomes dong mRNA.

Puromycin

Binds to the C-terminus of the growing polypeptide causing premature termination of the chain from the ribosome in both eukaryotes and prokaryotes.

Actinomycin

Inhibits the action of RNA polymerase and the synthesis of RNA.

Bacterial Ribosomes

$70S$ ribosomes composed of $30S$ and $50S$ subunits.

Eukaryotic Ribosomes

$80S$ ribosomes composed of $40S$ and $60S$ subunits.

Bacterial Initiator Amino Acid

F-Met carried by the initiator tRNA.

Eukaryotic Initiator Amino Acid

Met carried by the initiator tRNA.