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Last updated 3:41 AM on 9/13/26
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1
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Which system works most closely with the endocrine system to maintain homeostasis?

A) Respiratory system

B) Nervous system

C) Digestive system

D) Urinary system

E) Lymphatic system

B) Nervous system

2
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Endocrine glands differ from exocrine glands because endocrine glands:

A) Have ducts

B) Release only digestive enzymes

C) Release hormones into interstitial fluid and blood

D) Release secretions onto body surfaces

E) Produce only steroid hormones


C) Release hormones into interstitial fluid and blood

3
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Which structure controls the anterior pituitary by releasing regulatory hormones?

A) Thyroid gland

B) Hypothalamus

C) Pineal gland

D) Adrenal cortex

E) Pancreas

B) Hypothalamus

4
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Which anterior pituitary hormone stimulates the thyroid gland?

A) ACTH

B) FSH

C) TSH

D) GH

E) ADH

C) TSH

5
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Which anterior pituitary hormone stimulates the adrenal cortex?

A) ACTH

B) TSH

C) Prolactin

D) Oxytocin

E) FSH

A) ACTH

6
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Which hormone primarily stimulates general body growth?

A) Calcitonin

B) Growth hormone

C) Aldosterone

D) Insulin

E) Melatonin

B) Growth hormone

7
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Which hormone is released from the posterior pituitary and increases water reabsorption by the kidneys?

A) TSH

B) ACTH

C) ADH

D) GH

E) FSH

C) ADH

8
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Oxytocin is most directly involved in:

A) Lowering blood glucose

B) Increasing blood calcium

C) Uterine contractions and milk ejection

D) Increasing BMR

E) Increasing sodium retention

C) Uterine contractions and milk ejection

9
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Which gland produces melatonin?

A) Thyroid

B) Pineal

C) Pituitary

D) Thymus

E) Adrenal

B) Pineal

10
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Melatonin is particularly important for regulating:

A) Blood calcium

B) Blood glucose

C) Sleep and circadian rhythms

D) Sodium concentration

E) RBC production

C) Sleep and circadian rhythms

11
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Which hormones increase basal metabolic rate?

A) T3 and T4

B) Insulin and glucagon

C) FSH and LH

D) ADH and oxytocin

E) PTH and calcitonin

A) T3 and T4

12
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Which hormone lowers blood calcium levels?

A) PTH

B) Calcitriol

C) Calcitonin

D) Aldosterone

E) Cortisol

C) Calcitonin

13
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Which hormone increases blood calcium concentration?

A) Calcitonin

B) Parathyroid hormone

C) Insulin

D) Melatonin

E) Prolactin

B) Parathyroid hormone

14
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The major mineralocorticoid secreted by the adrenal cortex is:

A) Cortisol

B) Aldosterone

C) Epinephrine

D) Glucagon

E) Testosterone

B) Aldosterone

15
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Aldosterone primarily causes the kidneys to increase reabsorption of:

A) Sodium

B) Glucose

C) Calcium

D) Urea

E) Bilirubin

A) Sodium

16
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Which hormone is the major glucocorticoid?

A) Insulin

B) Cortisol

C) Aldosterone

D) Calcitonin

E) Melatonin

B) Cortisol

17
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Which is NOT a typical effect of glucocorticoids?

A) Increased glucose formation

B) Protein breakdown

C) Fat breakdown

D) Reduction of inflammation

E) Increased production of every type of blood cell

E) Increased production of every type of blood cell

18
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Which pancreatic cells produce insulin?

A) Alpha cells

B) Beta cells

C) Delta cells

D) Acinar cells

E) F cells

B) Beta cells

19
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Which pancreatic cells produce glucagon?

A) Alpha cells

B) Beta cells

C) Delta cells

D) Chief cells

E) Parietal cells

A) Alpha cells

20
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A decrease in blood glucose stimulates secretion of:

A) Insulin

B) Calcitonin

C) Glucagon

D) Aldosterone

E) Prolactin

C) Glucagon

21
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True or False: Insulin decreases blood glucose concentration.


True

22
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Excessive thyroid hormone would most likely cause:

A) Decreased metabolic rate

B) Weight gain from reduced metabolism

C) Increased metabolic rate and possible weight loss

D) Decreased body temperature

E) Decreased cellular respiration


C) Increased metabolic rate and possible weight loss

23
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Blood is classified as which type of tissue?

A) Epithelial

B) Nervous

C) Connective

D) Muscle

E) Adipose

C) Connective

24
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Approximately what percentage of whole blood is plasma?

A) 25%

B) 35%

C) 45%

D) 55%

E) 75%

D) 55%

25
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Formed elements make up approximately what percentage of blood?

A) 10%

B) 25%

C) 45%

D) 55%

E) 90%

C) 45%

26
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The percentage of total blood volume occupied by RBCs is called the:

A) Differential count

B) Hematocrit

C) Hemostasis

D) Hemolysis

E) Plasma volume

B) Hematocrit

27
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Plasma is composed primarily of:

A) Protein

B) Glucose

C) Water

D) RBCs

E) Electrolytes

C) Water

28
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Which plasma protein contributes most importantly to blood osmotic pressure?

A) Albumin

B) Hemoglobin

C) Fibrin

D) Myoglobin

E) Transferrin

A) Albumin

29
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Which category of plasma proteins includes antibodies?

A) Albumins

B) Globulins

C) Fibrinogens

D) Hemoglobins

E) Myoglobins

B) Globulins

30
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Which plasma protein is important for blood clotting?

A) Albumin

B) Fibrinogen

C) Hemoglobin

D) Myoglobin

E) Insulin


B) Fibrinogen

31
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Mature erythrocytes normally:

A) Contain large nuclei

B) Have no nucleus

C) Divide by mitosis

D) Produce antibodies

E) Become macrophages

B) Have no nucleus

32
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The biconcave shape of erythrocytes helps:

A) Reduce oxygen transport

B) Increase surface area for gas exchange

C) Produce antibodies

D) Cause clotting

E) Produce leukocytes

B) Increase surface area for gas exchange

33
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The oxygen-binding portion of hemoglobin is the:

A) Globin

B) Heme

C) Albumin

D) Fibrin

E) Plasma

B) Heme

34
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The iron found in hemoglobin directly binds:

A) Carbon dioxide

B) Oxygen

C) Nitrogen

D) Glucose

E) Sodium

B) Oxygen

35
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Normal RBC life span is approximately:

A) 10 days

B) 30 days

C) 60 days

D) 120 days

E) 365 days

D) 120 days

36
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Old erythrocytes are primarily removed by macrophages in the:

A) Pancreas and kidneys

B) Spleen and liver

C) Thyroid and thymus

D) Heart and lungs

E) Stomach and intestine

B) Spleen and liver

37
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Which hormone stimulates erythrocyte production?

A) TPO

B) EPO

C) TSH

D) ADH

E) ACTH


B) EPO

38
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Hematopoiesis occurs primarily in:

A) Yellow bone marrow

B) Red bone marrow

C) Cartilage

D) Lymph

E) Plasma

B) Red bone marrow

39
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Which formed element is primarily responsible for reducing blood loss after vessel injury?

A) Erythrocyte

B) Platelet

C) Lymphocyte

D) Eosinophil

E) Monocyte

B) Platelet

40
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Which leukocyte commonly becomes a macrophage after entering tissues?

A) Basophil

B) Monocyte

C) Eosinophil

D) Lymphocyte

E) Platelet

B) Monocyte

41
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Which leukocyte is most closely associated with releasing substances that promote inflammation?

A) Basophil

B) Erythrocyte

C) Platelet

D) Monocyte

E) Lymphocyte

A) Basophil

42
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Which leukocyte is associated with destroying antigen-antibody complexes and combating parasites?

A) Basophil

B) Eosinophil

C) Monocyte

D) Platelet

E) Erythrocyte

B) Eosinophil

43
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A person with type O blood has which antibodies in plasma?

A) Anti-A only

B) Anti-B only

C) Both anti-A and anti-B

D) Neither anti-A nor anti-B

E) Anti-Rh only

C) Both anti-A and anti-B

44
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True or False: A person with type AB blood has both A and B antigens on the RBC surface.

True

45
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The heart is located primarily within the:

A) Abdominal cavity

B) Mediastinum

C) Pelvic cavity

D) Cranial cavity

E) Vertebral cavity

B) Mediastinum

46
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The apex of the heart points:

A) Superiorly and right

B) Inferiorly and left

C) Directly posteriorly

D) Superiorly and left

E) Inferiorly and right

B) Inferiorly and left

47
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The tough outer portion of the pericardium is the:

A) Endocardium

B) Fibrous pericardium

C) Myocardium

D) Visceral pleura

E) Tunica externa

B) Fibrous pericardium

48
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Pericardial fluid primarily:

A) Increases friction

B) Reduces friction as the heart beats

C) Causes cardiac contraction

D) Carries oxygen

E) Produces action potentials

B) Reduces friction as the heart beats

49
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Which layer is both part of the heart wall and the visceral layer of the serous pericardium?

A) Endocardium

B) Myocardium

C) Epicardium

D) Fibrous pericardium

E) Parietal pericardium


C) Epicardium

50
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The thick muscular middle layer of the heart is the:

A) Epicardium

B) Myocardium

C) Endocardium

D) Pericardium

E) Endothelium

B) Myocardium

51
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Which heart chamber has the thickest myocardium?

A) Right atrium

B) Left atrium

C) Right ventricle

D) Left ventricle

E) All are equal

D) Left ventricle

52
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Why is the left ventricular wall thicker than the right ventricular wall?

A) It receives venous blood

B) It pumps through the systemic circulation

C) It pumps only to the lungs

D) It contains the SA node

E) It contains less blood


B) It pumps through the systemic circulation

53
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Blood returning from systemic circulation first enters the:

A) Left atrium

B) Right atrium

C) Left ventricle

D) Right ventricle

E) Pulmonary trunk

B) Right atrium

54
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Blood returning from the lungs first enters the:

A) Right atrium

B) Right ventricle

C) Left atrium

D) Left ventricle

E) Aorta

C) Left atrium

55
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Which valve lies between the right atrium and right ventricle?

A) Mitral

B) Aortic

C) Tricuspid

D) Pulmonary

E) Bicuspid

C) Tricuspid

56
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Which valve lies between the left atrium and left ventricle?

A) Tricuspid

B) Pulmonary semilunar

C) Mitral

D) Aortic semilunar

E) Coronary

C) Mitral

57
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The pulmonary semilunar valve prevents blood from returning from the:

A) Aorta into the left ventricle

B) Pulmonary trunk into the right ventricle

C) Right ventricle into the right atrium

D) Left ventricle into the left atrium

E) Vena cava into the right atrium

B) Pulmonary trunk into the right ventricle

58
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Chordae tendineae attach the AV valve cusps to the:

A) SA node

B) Papillary muscles

C) Semilunar valves

D) Aorta

E) Interatrial septum

B) Papillary muscles

59
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Contraction of papillary muscles helps prevent:

A) Opening of semilunar valves

B) AV valve prolapse into the atria

C) Blood entering the ventricles

D) Depolarization

E) Blood entering the coronary circulation

B) AV valve prolapse into the atria

60
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The normal pacemaker of the heart is the:

A) AV node

B) SA node

C) Bundle of His

D) Purkinje fibers

E) Medulla

B) SA node

61
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Which sequence correctly represents the cardiac conduction pathway?

A) AV node → SA node → Purkinje fibers → bundle branches

B) SA node → AV node → AV bundle → bundle branches → Purkinje fibers

C) Purkinje fibers → SA node → AV node → AV bundle

D) SA node → Purkinje fibers → AV node → ventricles

E) AV bundle → SA node → AV node → Purkinje fibers


B) SA node → AV node → AV bundle → bundle branches → Purkinje fibers

62
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On an ECG, the P wave represents:

A) Ventricular depolarization

B) Atrial depolarization

C) Ventricular repolarization

D) Atrial repolarization only

E) Valve closure

B) Atrial depolarization

63
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The QRS complex represents:

A) Atrial depolarization

B) Ventricular depolarization

C) Ventricular repolarization

D) Atrial filling

E) Semilunar valve closure

B) Ventricular depolarization

64
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The T wave represents:

A) Atrial depolarization

B) Ventricular depolarization

C) Ventricular repolarization

D) SA node firing only

E) AV valve opening

C) Ventricular repolarization

65
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Parasympathetic stimulation through the vagus nerve causes:

A) Increased heart rate

B) Decreased heart rate

C) Increased blood viscosity

D) Increased blood volume

E) Ventricular fibrillation

B) Decreased heart rate

66
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Cardiac output equals:

A) HR ÷ SV

B) HR × SV

C) EDV + ESV

D) SV ÷ HR

E) BP × resistance


B) HR × SV

67
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Which vessels carry blood away from the heart?

A) Veins

B) Arteries

C) Venules

D) Capillaries

E) Sinusoids

B) Arteries

68
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Which vessels return blood toward the heart?

A) Arteries

B) Arterioles

C) Veins

D) Capillaries

E) Metarterioles

C) Veins

69
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The innermost layer of a blood vessel is the:

A) Tunica externa

B) Tunica media

C) Tunica interna

D) Myocardium

E) Endocardium

C) Tunica interna

70
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Which blood-vessel layer contains large amounts of smooth muscle?

A) Tunica interna

B) Tunica media

C) Tunica externa

D) Endothelium only

E) Basement membrane

B) Tunica media

71
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Vasoconstriction is mainly produced by contraction of smooth muscle in the:

A) Tunica interna

B) Tunica media

C) Tunica externa

D) Capillary basement membrane

E) Endocardium

B) Tunica media

72
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Arterioles are known as resistance vessels because they:

A) Have valves

B) Strongly regulate vessel diameter and blood flow

C) Carry the greatest blood volume

D) Lack smooth muscle

E) Have the thinnest walls

B) Strongly regulate vessel diameter and blood flow

73
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Vasodilation causes vessel diameter to:

A) Decrease

B) Increase

C) Remain unchanged

D) Completely close

E) Reverse blood flow

B) Increase

74
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Which are the main exchange vessels?

A) Arteries

B) Arterioles

C) Capillaries

D) Veins

E) Venules


C) Capillaries

75
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Capillary walls are well suited for exchange because they are:

A) Thick and muscular

B) Very thin

C) Covered with cartilage

D) Highly keratinized

E) Made of skeletal muscle


B) Very thin

76
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Which capillary type has pores that allow greater exchange and is found in organs such as the kidneys?

A) Continuous

B) Fenestrated

C) Muscular

D) Elastic

E) Venous

B) Fenestrated

77
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Which capillaries have large openings and an incomplete basement membrane?

A) Continuous capillaries

B) Fenestrated capillaries

C) Sinusoids

D) Arterioles

E) Venules

C) Sinusoids

78
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Precapillary sphincters regulate:

A) Heart rate

B) Blood flow through capillary beds

C) Formation of RBCs

D) Blood clotting

E) Venous valves

B) Blood flow through capillary beds

79
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Blood hydrostatic pressure tends to:

A) Pull fluid into capillaries

B) Push fluid out of capillaries

C) Destroy RBCs

D) Close veins

E) Decrease filtration

B) Push fluid out of capillaries

80
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Blood colloid osmotic pressure tends to:

A) Push fluid out of capillaries

B) Pull fluid into capillaries

C) Close capillary beds

D) Increase RBC production

E) Cause vasoconstriction

B) Pull fluid into capillaries

81
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A decrease in plasma proteins would most likely contribute to:

A) Increased reabsorption

B) Edema

C) Increased blood colloid osmotic pressure

D) Reduced filtration

E) Increased hematocrit

B) Edema

82
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Which factor most strongly assists venous return from the limbs?

A) Skeletal muscle activity

B) Hematocrit

C) Plasma proteins

D) RBC destruction

E) Platelet activation

A) Skeletal muscle activity

83
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Valves in veins primarily:

A) Increase arterial pressure

B) Prevent backward blood flow

C) Cause vasoconstriction

D) Produce blood cells

E) Perform gas exchange

B) Prevent backward blood flow

84
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An increase in blood viscosity generally causes vascular resistance to:

A) Decrease

B) Increase

C) Remain unchanged

D) Become zero

E) Reverse

B) Increase

85
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Which variable most directly increases resistance when it decreases?

A) Blood-vessel lumen diameter

B) Blood oxygen

C) Plasma glucose

D) Heart size

E) Body temperature

A) Blood-vessel lumen diameter

86
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A decrease in baroreceptor firing caused by low blood pressure produces:

A) Increased parasympathetic stimulation

B) Increased sympathetic stimulation

C) Lower heart rate

D) Lower contractility

E) Vasodilation only

B) Increased sympathetic stimulation

87
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The radial artery is commonly used to measure a pulse at the:

A) Neck

B) Wrist

C) Ankle

D) Groin

E) Chest

B) Wrist

88
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A blockage of the external iliac artery would most directly reduce blood flow into the:

A) Renal artery

B) Femoral artery

C) Carotid artery

D) Mesenteric artery

E) Coronary artery

B) Femoral artery

89
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One major function of the lymphatic system is to:

A) Pump blood

B) Drain excess interstitial fluid

C) Produce bile

D) Produce urine

E) Secrete insulin

B) Drain excess interstitial fluid

90
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Specialized lymphatic capillaries in the small intestine that absorb dietary lipids are called:

A) Sinusoids

B) Lacteals

C) Venules

D) Alveoli

E) Glomeruli

B) Lacteals

91
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Interstitial fluid is called lymph once it:

A) Enters blood capillaries

B) Enters lymphatic vessels

C) Enters the stomach

D) Reaches the kidneys

E) Reaches the liver

B) Enters lymphatic vessels

92
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Lymphatic capillaries begin as:

A) Closed-ended tubes

B) Arteries

C) Veins

D) Open cavities connected to the heart

E) Ventricles

A) Closed-ended tubes

93
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Which duct drains most of the body?

A) Right lymphatic duct

B) Thoracic duct

C) Cystic duct

D) Pancreatic duct

E) Common bile duct

B) Thoracic duct

94
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The right lymphatic duct drains the:

A) Entire lower body

B) Right upper portion of the body

C) Entire left side
D) Abdominal organs only

E) Lower limbs only

B) Right upper portion of the body

95
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The thoracic duct ultimately returns lymph near the:

A) Left subclavian vein

B) Right femoral vein

C) Inferior vena cava

D) Pulmonary trunk

E) Aorta

A) Left subclavian vein

96
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Which lymphatic trunk drains the head and neck?

A) Lumbar

B) Jugular

C) Intestinal

D) Bronchomediastinal

E) Subclavian

B) Jugular

97
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Which lymphatic trunk primarily drains the upper extremity?

A) Jugular

B) Intestinal

C) Subclavian

D) Lumbar

E) Bronchial

C) Subclavian

98
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Which organ filters blood rather than lymph?

A) Lymph node

B) Spleen

C) Tonsil

D) Thymus

E) Lacteal

B) Spleen

99
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The spleen contains:

A) Gray and white matter

B) Red and white pulp

C) Cortex and medulla only

D) Glomeruli and tubules

E) Alveoli and bronchioles

B) Red and white pulp

100
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Which is NOT considered a lymphatic organ or structure?

A) Spleen

B) Thymus

C) Lymph node

D) Pancreas

E) Tonsil

D) Pancreas