Exam One Medications

Imuran generic name

Azathioprine

Azathioprine type

antimetabolite

Azathioprine action

decrease T&B cell proliferation

Azathioprine adverse effects

bone marrow supression

Azathioprine Black Box

Increased risk for malignancy with chronic use

Azathioprine forms

oral and iv

Azathioprine Nursing considerations

monitor CBC and liver function

Simulect generic name

Basiliximab

Basiliximab type

monoclonal antibody

Basiliximab action

prevent t cell proliferation

Basiliximab form

IV only

Basiliximab adverse effects

infection, hypertension, anaphylaxis

Basiliximab usage

kidney transplant

Basiliximab nursing consideration

monitor infections and hypertension

Cyclosporine type

inhibit calcineurin

Cyclosporine action

inhibit t cell activation

Cyclosporine adverse effects

temor, gingival hyperplasia, hypertrichosis

Cyclosporine black box

nephrotoxicity

Cyclosporine nursing consideration

kidney function, BP and drug levels - NO GRAPEFRUIT

Cyclosporine form

oral and IV

Rapamune generic name

Sirolimus

Sirolimus type

mTOR inhibitor

Sirolimus action

decrease t cell proliferation and action

Sirolimus form

oral only

Sirolimus adverse effect

hyperlipidemia

Sirolimus black box

infection and malignancy → not for lung or kidney transplant patients

Sirolimus nursing considerations

monitor CBC, lipids, kidney and liver func

Prograf generic name

Tacrolimus

Tacrolimus type

cyclosporin similarities

Tacrolimus black box

lymphoma and skin cancers

Tacrolimus nursing considerations

glucose and potassium levels

cellcept and myfortic generic name

Mycophenolate mofetil

Mycophenolate mofetil type

antimetabolite as well

Mycophenolate mofetil action

decrease t cell proliferation

Mycophenolate mofetil adverse effects

bone marrow supression

Mycophenolate mofetil black box

pregnancy loss and congenital malformation

Mycophenolate mofetil nursing considerations

magnesium/aluminum containing antacids decrease the absorption