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Neurons
Specialized for communication using electrical and chemical signals.
Glia
“Nerve glue’”; non-electrical cells that support neuronal signaling, provide nutrients, and guide neurons in development.
Gene expression
Defines the type and functions of cells in the nervous system.
Brain energy use
The brain is 2% of body mass but uses 25% of daily energy production.
Has ~86 billion neurons.
Human brain neurons
Synapses
The locations where communication between neurons occurs.
Afferent
Message towards brain and sensory neurons
Sensory neurons
Carry information to the CNS
Efferent
Message away from brain.
Motor neurons
Carry information from the CNS to the muscles
Interneurons
Message between neurons.
Dendrites
Parts of a neuron that receive signals from other cells.
Cell body (soma)
The main part of a neuron containing the cell's central components.
Axon
Part of a neuron through which electrical signals spread.
Axon terminals
Parts of a neuron where transmitter release is triggered.
Node of Ranvier
Gaps in myelin where ion channels are densely packed.
Myelin sheath
A covering that wraps around and insulates an axon.
Glial cell types
Astrocytes, microglia, oligodendrocytes, and Schwann cells.
Astrocytes
Cells involved in development, energy and metabolism, synaptic functions, and maintenance of the blood brain barrier.
Microglia
The “immune system” in the brain; eliminate synapses and provide signaling to other cells.
Oligodendrocytes
Myelinate the central nervous system.
Schwann cells
Myelinate the peripheral nervous system.
Central Nervous System (CNS)
Brain and spinal cord.
Peripheral Nervous System (PNS)
Peripheral motor and sensory nerves.
Somatic nervous system
Includes sensory nerves that carry information to the CNS and motor nerves that carry information from the CNS to the muscles.
Sensory nerves
Carry information to the CNS.
Motor nerves
Carry information from the CNS to the muscles.
Autonomic nervous system
Division responsible for involuntary functions and includes sympathetic and parasympathetic systems.
Sympathetic
Fight or flight response.
Parasympathetic
Rest and digest.
Cranial nerves
12 nerve pairs that enter and exit directly from the brain and innervate the face, head and neck, plus the vagus nerve.
Neural circuit
A group of neurons connected by synapses that process specific types of information.
Patellar reflex
Stretch of the patellar tendon causes the quadriceps muscle to stretch, sensory nerves send a signal to the spinal cord, and motor neurons cause the quadriceps to contract.
Bilateral symmetry
Left and right hemispheres of the brain and spinal cord are nearly mirror images.
Brain hemispheres
Despite similar appearance, the left and right sides are not identical in function.
Split brain
A condition used to demonstrate differences in function between the left and right hemispheres.
Meninges
Protective layer around the brain and spinal cord.
Dorsal horn
Contains sensory interneurons
Ventral horn
Contains motor neurons.
Dorsal & Ventral root
A bundle through which axons emerge from the spinal cord.
Mixed nerve
Formed when dorsal and ventral roots merge.
Spinal cord tracts
Carry sensory and motor information to and from the brain.
Spinal nerves
31 pairs of nerve bundles containing many axons that exit between vertebrae.
Cerebrospinal fluid
Cushions and protects the brain and exchanges material between blood and brain.
Choroid plexus
A tissue found suspended in ventricles that makes cerebrospinal fluid
Ventricular system
A system in which cerebrospinal fluid is found and through which fluid flows directionally.
Subarachnoid space
A space where cerebrospinal fluid is found.
Cerebrospinal fluid flow
Lateral → 3rd → 4th → central canal.
Vascular system
Provides nutrients and energy and carries away waste.
Gray matter
Cell bodies and dendrites.
White matter
Myelinated axons.
Electrical and chemical signals
Neurons are specialized for communication using both types of signals.
7,000
A typical neuron has what number synaptic partners.
400
A typical neuron can send up to # messages per second.
Action potential
Electrical signal that spreads through a neuron across the axon and triggers transmitter release to synaptic partners.
Neurotransmitter
Chemical signal released to transfer information between neurons.
Chemical signals
Excite or inhibit action potentials in the receiving neuro
Presynaptic terminal
Axon portion involved in releasing neurotransmitter.
Postsynaptic terminal
Dendrite portion that receives neurotransmitter signals.
Synaptic cleft
Space between communicating neurons where neurotransmitter is released.
Vesicle
Structure that stores transmitter before release.
Receptor
A structure that binds a specific neurotransmitter.
Presynaptic neuron
Stores transmitter in vesicles.
Glutamate
A neurotransmitter that can excite neurons.
GABA
A neurotransmitter that can inhibit neurons.
Dopamine
A neurotransmitter that can excite, inhibit, or modulate neuronal activity.
Serotonin
A neurotransmitter that can excite, inhibit, or modulate neuronal activity.
Norepinephrine
A neurotransmitter that can excite, inhibit, or modulate neuronal activity.
Excitatory post-synaptic potential EPSP
A brief electrical change to excite a neuron, making an action potential more likely.
Inhibitory post-synaptic potential (IPSP)
A brief electrical change to inhibit a neuron, making an action potential less likely.
Transmitter release
An action potential initiates the release of neurotransmitter into the synaptic cleft
Postsynaptic receptor binding
Transmitter binds to post-synaptic receptors and produces an electrical change
Transmitter breakdown
After the action potential has ended, all transmitter has been broken down
Resting return
If the post-synaptic neuron did not reach threshold, it returns to rest.
Electrical synapse
A connexon physically bridges two neurons and allows both electrical signals and small molecules to pass between the neurons in both directions
Connexon
Physically bridges two neurons.
Threshold
The electrical potential that must be reached to trigger an action potential.
Firing frequency
The frequency of action potentials used to encode information
Sensory neuron response to light touch
Generates an action potential.
Sensory neuron response to strong touch
Generates action potentials more frequently.
Spontaneous firing
A motor neuron can be spontaneously active.
Inhibitory input
Causes a spontaneously active motor neuron to fire action potentials less frequently.
Excitatory input
Causes a spontaneously active motor neuron to fire action potentials more frequently.
Simple reflex circuit
Toe sensory neuron → spine interneuron → motor neuron that controls skeletal muscle in the foot.
Sub-threshold touch
Light touch produces only spontaneous motor neuron firing.
Strong toe pinch
Produces strong activity in the interneuron, more motor neuron firing, muscle contraction, and foot withdrawal.
Parallel processing
Information spreads along multiple pathways.
Feedback
Neurons influence their own inputs.
Balance
Excitation vs inhibition.
Reverberatory activity
Allows neurons to stay active for longer periods of time.
Working memory
Can be maintained through reverberatory activity.
Divergent connections
A small number of neurons broadcast a message to a large number of recipients.
Midbrain dopaminergic neurons
An example of neurons involved in divergent connections.
Convergent connections
Many different neurons send signals to a small number of recipient neurons.
Volt
Unit used to measure electrical potential.
Current
The flow of charge over time.
Amp
Unit used to measure current.
Conductance
The more channels open, the higher the conductance.
Siemens
Unit used to measure conductance.
Membrane potential
Electrical potential measured inside cells relative to outside.