OIA1008 SURFACTANTS

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40 Terms

1
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What is a surfactant?

A substance that adsorbs onto surfaces/interfaces at low concentration and significantly reduces surface or interfacial tension.

2
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What is the main role of surfactants in pharmacy?

To reduce surface/interfacial tension, enabling emulsification, solubilization, dispersion, and improved drug bioavailability.

3
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Why are surfactants called amphiphilic?

They have both hydrophilic (water-loving) heads and hydrophobic (oil-loving) tails.

4
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How do surfactants lower surface tension at the air-water interface?

By disrupting cohesive forces between water molecules.

5
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What are the four types of surfactants based on charge?

Anionic, cationic, nonionic, and zwitterionic (amphoteric).

6
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What is the defining feature of anionic surfactants?

They have a negatively charged hydrophilic group.

7
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When are anionic surfactants most effective?

In removing dirt, clay, and oily stains—used in soaps and shampoos.

8
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Give an example of an anionic surfactant used in personal care.

Sodium lauryl sulfate (SLS), used in toothpastes and shampoos.

9
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What is SDS and where is it used?

Sodium dodecyl sulfate—used in hygiene and cleaning products.

10
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How are anionic surfactants like soaps obtained?

Via saponification of triglycerides (fats) with alkali.

11
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What charge do cationic surfactants carry?

Positive charge on their hydrophilic group.

12
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Where are cationic surfactants commonly used?

In antistatic products like fabric softeners and as disinfectants.

13
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Name a cationic surfactant with antimicrobial activity.

Cetylpyridinium chloride—used in mouthwashes and lozenges.

14
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What makes amphoteric surfactants unique?

They have both positive and negative charges depending on pH.

15
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What are the advantages of amphoteric surfactants?

Low toxicity, antibacterial properties, and compatibility with other surfactants.

16
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Give an example of a zwitterionic surfactant used in cosmetics.

Cocamidopropyl betaine—used in shampoos and body washes.

17
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What distinguishes nonionic surfactants?

They lack charge and are based on hydrophilic EO chains.

18
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Where are nonionic surfactants commonly used?

As emulsifiers and foaming agents in pharmaceuticals.

19
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Name a nonionic surfactant used in drug formulations.

Polysorbate 20 (Tween 20)—used to stabilize emulsions.

20
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What does the HLB value of a surfactant represent?

The balance between its hydrophilic and lipophilic parts.

21
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What does a low HLB value (<10) indicate?

The surfactant is more lipophilic—suitable for W/O emulsions.

22
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What does a high HLB value (>10) indicate?

The surfactant is more hydrophilic—suitable for O/W emulsions.

23
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How does ethoxylation affect HLB?

More EO units = higher HLB = more water solubility.

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What is a micelle?

An aggregate of surfactant molecules with hydrophobic cores and hydrophilic shells.

25
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What is the critical micelle concentration (CMC)?

The minimum surfactant concentration required to form micelles.

26
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What drives micelle formation thermodynamically?

Decreased system free energy via hydrophobic fragment removal and hydrogen bond formation.

27
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How can micelle size and shape be controlled?

By adjusting surfactant structure, concentration, pH, and ionic strength.

28
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How does counterion affect micelle size in anionic surfactants?

Larger counterions (e.g., Cs⁺) increase micelle size: Na⁺ < K⁺ < Cs⁺.

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What is micellar solubilization?

Increasing solubility of poorly water-soluble drugs via entrapment in micelles.

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What role does CMC play in solubilization?

Solubilization begins at or above the CMC.

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What happens when micelle concentration increases?

Drug solubility increases proportionally.

32
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Name surfactants approved by the FDA for parenteral solubilization.

Polysorbate 20, 40, 80; monopalmitate; polyoxyethylated fatty acids.

33
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How do surfactants aid emulsification?

By reducing interfacial tension between oil and water phases.

34
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How do surfactants assist in drug delivery systems?

By improving drug solubility, stability, and absorption.

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Why are surfactants included in topical formulations?

For spreading, wetting, and enhanced skin penetration.

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How do surfactants function in oral care products?

As antimicrobial and foaming agents (e.g., cetylpyridinium chloride in mouthwash).

37
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What is the critical micellization temperature (CMT)?

The temperature above which micelles start forming.

38
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How can micelles change structure?

Spherical → cylindrical → bilayers, depending on surfactant properties.

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How does ionic strength influence micellization?

Higher ionic strength often promotes larger micelles due to charge shielding.

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What is the pharmaceutical relevance of micelle formation?

Allows formulation of injectable and oral drugs that are otherwise water-insoluble.