AP bio unit 5

Phenotype

Phenotype

The observable traits or characteristics of an organism

Genotype

The genetic makeup of an organism, determined by the combination of alleles for a particular trait. It refers to the specific genes an individual carries, which may or may not be expressed in their phenotype.

What do you do to determine the probability of A or B happening? (they are mutually exclusive)

add the two probabilities

What do you do to determine the probability of A and B happening? (they are independent of each other)

multiply the two probabilities

Homozygous

having two identical alleles for a particular gene. (Ex. AA or aa)

Heterozygous

Having two different alleles for a particular gene. (Ex. Aa)

On a pedigree, what does a circle represent?

a female

On a pedigree, what does a square represent?

a male

On a pedigree, what does a shaded circle/square represent?

this person has the trait that is being studied

On a pedigree, what does a unshaded circle/square represent?

this person does not have the trait that is being studied

On a pedigree, what does a half-shaded circle/square represent?

this person is a carrier for the trait being studied (will be heterozygous)

On a pedigree what is a marriage and sibling line?

Show family relations

Autosomal

a gene not located on a sex chromosome

Sex-linked

a gene located on a sex chromosome (X or Y)

In a dihybrid cross, if two parents, heterozygous for both alleles are crossed what is the phenotypic ratio?

9 dominant for both traits: 3 dominant for one trait: 3 dominant for the other trait: 1 recessive for both traits

Incomplete dominance

the phenotype of the heterozygote is an intermediate between the two homozygotes (Ex. if a red flower (AA) breeds with a white flower (aa), its offspring (Aa) will be pink)

Codominance

neither allele is dominant and the heterozygote shows both aspects of the phenotype (Ex if a red flower (AA) breeds with a white flower (aa), its offspring (AA) will be white with red spots)

Multiple alleles

more than two alleles exist for each gene but each individual only has two (Ex. for flower color alleles exist for purple, red, white, blue, yellow, etc. but a individual plant will only have at most two different ones)

4 rules for x-linked pedigrees

1. affected mothers must have affected sons

2. if both parents are affected all children will be affected

3. unaffected fathers will have no affected daughters

4. unaffected mothers can have both affected or unaffected sons when heterozygous

Polygenic traits

genetic traits that are controlled by more than one gene

non-nuclear inheritance

traits that are controlled by genes on DNA that is not located in the nucleus (they are on mitochondrial or chloroplast DNA). Mitochondria are transmitted to the egg but not the sperm during reproduction so traits controlled by the mitochondria are maternally inherited and a female with the trait will pass it to all her offspring.

Genotype of the 4 different blood types?

Shown in picture, if A and B are together they are codominant but i is just recessive.

non-mendelian patterns of inheritance

they do not follow the ratios predicted by Mendel’s law. (Ex. sex linked and linked genes)

linked genes

genes located near each other on the same chromosome and they are usually inherited together unless separated during crossing over

map distance

how close together a pair of linked genes is and it is found by looking at the percent of time they are separated

How to tell if a gene is linked or not?

If your observed ratios are close to the expected ratios then they are not linked

recombinant phenotypes

Recombinant phenotypes are offspring with new combinations of traits different from their parents. (Ex. If red flower and white flower produce offspring, the offspring that are pink have recombinant phenotypes.)

parental phenotypes

phenotypes that are the same as the parents (Ex. If red flower and white flower produce offspring, the offspring that are red or white have parental phenotypes.)

recombination frequency

calculated by taking the number of individuals with recombinant phenotypes and dividing by total number of individuals and then multiplied by 100. This will give you percent which is equal to map units which is the distance between the genes on the chromosome

Autosomal dominant

caused by a mutation in a gene on one of the autosomes (1-22) and its inherited the same way in males and females. (AA, Aa are affected and aa are unaffected)

autosomal recessive

caused by a mutation in a gene on one of the autosomes (1-22) and inherited the same way in males and females. (AA, Aa unaffected and aa are affected)

X-linked recessive

caused by mutation on the X chromosome so it is expressed differently in females and males. (X^A X^A, X^A X^a unaffected female X^aX^a affected female: X^A Y unaffected male, X^a Y affected male)

non-disjunction

failure of chromosomes to separate so result in one to many or one to little chromosomes

duplication

part of the chromosome duplicates

inversion

a part of the chromosome flips so it changes order or alleles

deletion

part of the chromosome gets deletes

insertion

a part of the chromosome transfers to another chromosome

translocation

two pieces of different chromosomes switch places

epigenetics

changes in gene expression that do not change the gene expression