1 - lymphoma, mast cell tumors

What viruses can cause an increased risk of developing lymphoma in cats

FeLV, FIV

T/F lymphoma in dogs can be hereditary

T

what is the most common form of lymphoma in cats

alimentary

what is the most common type of lymphoma in dogs

multicentric

What are some examples of paraneoplastic syndromes associated with lymphoma

hypercalcemia, cranial nerve paralysis, hyperglobulinemia, immune-mediated diseases, neuropathy, hypoglycemia

T/F Staging can be used to indicate prognosis

F

how are the majority of lymphoma cases diagnosed

cytology

what stage of lymphoma is limited to a solitary lymph node

stage I

what stage of lymphoma includes more than one lymph node but is isolated to one side of the diaphragm

stage 2

What stage of lymphoma is described by generalized lymph node involvement

stage 3

what stage of lymphoma is described by generalized lymph node involvement plus involvement of liver or spleen

stage 4

what stage of lymphoma is described by bone marrow or extra nodal involvement

stage 5

what substage of lymphoma is an asymptomatic patient

a

what substage of lymphoma is an ill/sick patient

b

which type of lymphoma is typically more responsive to treatment

B-cell

which type of lymphoma is typically less responsive to treatment

T-cell

How soon after beginning treatment can you get a good idea of how the patient is responding

4-6 weeks

what are the two most common side effects of chemotherapies

GI effects, myelosuppression

what is the only chemotherapy drug that is FDA approved to treat lymphoma

Tanovea

what is the most common cutaneous malignancy of dogs

mast cell tumors

what malfunctioning receptor is responsible for mast cell tumor formation

KIT

which mutation increases risk of mast cell tumor recurrence and metastasis

C-kit

what diagnostic test needs to be performed to obtain a grade on a mast cell tumor

histopath

what diagnostic tests can be performed to stage a mast cell tumor

regional LN examination/cytology, imaging

what are some negative factors of mast cell tumors

high grade tumors, regional node involvement, mucous membrane sites, high proliferation, presence of systemic illness, breed, active c-kit gene mutation, aberrant KIT localization

what adjunctive therapy should be given in addition to chemotherapy treatment of a mast cell tumor

diphenhydramine, H2 blocker or proton pump inhibitors

what are some options of local control of a mast cell tumor

surgery, radiation, stelfonta

what are some limitations of radiation as a treatment option of mast cell tumors

incomplete resection, tumors in difficult areas

does small or large cell pymphoma have a better prognosis

small

What term describes the microscopic assessment of a tumor’s aggressiveness

grading

what term describes the determination of the spread of a cancer throughout the body

staging

is grading or staging a better indication of prognosis

grading