Review of Powder Blending and Granulation

Flashcards created from lecture notes on types of blenders and granulation processes to aid in exam preparation.

What are the types of low shear blenders?

Tumble blenders, V-blenders, Ribbon blenders, Cone blenders, Double-cone blenders.

What is the primary purpose of granulation in powder processing?

To convert fine powder particles into larger granules for enhanced dosage form processing.

What are the advantages of granulation?

Improves powder flowability, compressibility, and uniformity; reduces issues of segregation and dust generation; enhances tablet properties.

What is wet granulation?

A process where a liquid is added to the powder and mixed to form granules, followed by drying to remove the liquid.

What stages occur in the wet granulation process?

Pre-granulation mixing, granulation, drying, mixing of extra-granular ingredients, and processing into dosage forms.

What is a key feature of high shear mixers used in wet granulation?

The design and speed of the impeller which influences the mixing of the powder blend with the liquid binder.

How does fluid bed granulation differ from traditional drying methods?

Fluid bed granulation suspends granules in hot air for faster and more efficient drying compared to tray drying.

What are the main factors affecting the growth of wet granules?

Particle size, solubility, binder properties, impeller speed and design, and mixing time.

What is the difference between dry granulation and wet granulation?

Dry granulation does not use liquids and is faster, while wet granulation improves content uniformity and can handle a wider range of powders.

What components are found in a roller compactor?

Powder feeding system, compaction unit, size reduction unit, and fines collecting tray.