Set 8: Plasma Proteins That Work with Complement

Q84. What does the blood coagulation system do? a) Minimizes blood loss b) Hinders entry of pathogens into blood circulation c) Platelets release prostaglandin and other factors to boost innate immune response d) All of the above

d

Q85. What does bradykinin do? a) Causes vasodilation and attracts innate immune cells b) Cleaves C3 c) Forms the MAC d) Opsonizes pathogens

a

Q86. What percentage of plasma proteins are protease inhibitors? a) 1% b) 5% c) 10% d) 25%

c

Q87. What does α2-macroglobulin do? a) Cleaves C3 b) Traps proteases — protease attack exposes internal thioester that bonds with protease; shape change encloses protease c) Forms the MAC d) Opsonizes pathogens

b

Q88. What are defensins? a) Large proteins b) Small (35-40 amino acids) amphipathic peptides c) Carbohydrates d) Lipids

b

Q89. Where are α-defensins made? a) Neutrophils and Paneth cells of small intestine b) Epithelial cells c) Liver cells d) Bone marrow

a

Q90. Where are β-defensins made? a) Neutrophils b) Various types of epithelial cells c) Liver cells d) Bone marrow

b

Q91. What is true about defensins evolutionarily? a) They are the newest immune defense mechanisms b) They are among the oldest immune defense mechanisms c) They only exist in humans d) They are not found in other animals

b

Q92. What do platelets release to boost innate immune response? a) Prostaglandin and other factors b) Antibodies c) Complement proteins d) Defensins

a

Q93. What does the blood coagulation system minimize? a) Blood loss b) Pathogen entry c) Inflammation d) Complement activation

a

Q94. What do defensins do to microbial membranes? a) Insert into membranes → form pores → pathogen leaks and dies b) Strengthen membranes c) Opsonize pathogens d) Cleave C3

a