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PTSD most effective and FDA approved tx (short)
SSRI
26 year old woman is worried about a presentation, avoids giving them, feels like she might vomit if in public or being looked at by others. she gets sweaty and shakes, this lasts for 10-30 mins. dx
social anxiety disorder
embarassement* (whereas specific phobia is a harmless object and panic disorder is UNEXPECTED attacks)
down syndrome
horizontal palmar crease
almond shaped eyes
hypoplastic face
prominent epicanthic folds
low set ears
protruding tongue
disheveled appearance, no wish for social contact, no history of psychotic behaviors, no interests in anything. dx
schizoid PD
pt in ER is depressed after husband died, she believes she was responsible for the car accident (despite not beign there), she lost a lot of weight and wants to die at home. she attempted suicide. what do you do?
arrange with psych to have her placed in involuntary psych hold as “immediate danger to self” and aggressively treat her overdose under daughter’s direction as her legal power of attorney
30 year old in labor has a severe phobia of needles, she gets scared and has no healthcare peroxy. she is screaming and in physical distress. her husband tells the team to perform the c-section. what happens next
she does NOT have decision-making capacity, and her husband can be consulted to advise the team on how to proceed
22 year old x 7 days says blood “is magical” and is very elated in mood, agitation quickly, distracted. dx
bipolar I disorder, manic state with psychotic features
(schizotypal would not suddenly occur for 7 days, it’s a longitudinal thing)
before you start 2nd gen antipsychotics with psychosis, what labs to do?
EKG
blood glucose
lipids
features of dependence syndrome
compulsion to continue to use
preoccupation with drug
neglect of alternative pleasures
impaired control
increased tolerance
disregarding known harmful effects
pt has chest pain for an hour but no evidence. he now avoids going out in case it happens again. he feels nervous. tx
cognitive behavioral therapy and SSRI med
(somatic sx disorder, maybe panic disorder)
vomits fresh red blood, makes herself vomit, okay weight, uses laxatives, she wants to lose 10 more lbs to be happy. dx
bulimia
pt says he wish he were dead, has rope, bankrupted his family (he did not). he wants to go home. what do you do?
place him in psych hold as imminent danger to himself and involuntarily admit into locked unit for observation and tx
NO major concerns, struggles to make friends, doesn’t understand other’s motivations, doesn’t show interest in other people, likes comic books. he has done ok in school. dx?
autism
pt has significant abdominal pain and back, very foxused, no findings at all. if there is no physical cause, what is dx?
somatic symptom disorder
when asked a question he repeats the last syllable of the last word in the sentence several times and talks about “omnimicrotask”
neologism and preservation
neologism
made up words
tangentiality definition
person's speech continuously drifts from the original topic without ever returning to the main point
(asked a question → starts answering and then goes into a side tangent and NEVER returns to the original question)
circumstantiality definition
speaker wanders off with excessive, unnecessary details but eventually returns to the original point
perseveration definition
repeating a word, phrase, topic or doing a specific action over and over
what is most important about OCD diagnosis?
checking if pt recognizes that their thoughts are irrational and still can’t change them
self inflicted cut, self harm but does not want to hurt herself. what do you want to do?
talk to mom with patient’s permission and with her, attempt to contact the psych about the self-harm, offer pt to return to ED if she feels like harming herself again
expelled from school, substance abuse, assault. dx?
antisocial personality disorder
socially withdrawn, frightened, concerned neighbors talk about him and can hear him. he thinks there has to be hidden cameras. his mood is euthymic. no drugs. dx?
schizophreniform
schizophreniform vs. schizoaffective
phreniform: 1-6 mos, not rlly mood changes
affective: long-term, manic/depressive
lithium toxicity steps
admit ICU, start IV, hemodialysis, get frequent lithium levels, renal function tests, electrolytes, neuro checks
absolute CI for ECT
increased intracranial pressure
which prof should coordinate all of a pt’s care with deteriorating memory if they don’t have a family/trusted person?
primary care team (MD and PA)
what 2 sx is this: hearing voices in head but can’t see them, has heard radio broadcaster speak directly to him on air.
auditory hallucinations with delusions of reference
what is delusion of reference vs. thought insertion
delusion of reference: misinterpreting neutral external events as having highly personal meaning
thought insertion: belief that external forces are placing foreign thoughts directly into one's mind
psychosis tx if 2nd gen antipsychotic does not work repeatedly?
oral clozapine (another 2nd gen antipsy, later resort)
pt says when she skips a dose, she sweats, shakes and feels physically sick and she has needed larger doses of this drug to achieve anxiety relief
benzo (ativan)
pt wants to end life, the doctors are busy. what do you do?
ask ER MD to initiate emergency (CPEP) involuntary hold for 72 hour observation as soon as one doctor is available
dopaminergic pathway for hyperprolactinemia
tuberinfundibular
nigrostriatal pathway
voluntary motor (EPS)
mesolimbic pathway
reward processing (positive sx of psychosis)
mesocortical pathway
executive fx (negative/cog sx of schizophrenia)
IQ 45 =
mod intellectual ability
most appropriate tx if she feels down, loses weight, wakes a lot at night, worsening mood and anhedonia
begin SSRI
forgetful, confused, 23/30 on MMSE, has HTN but no other hx. she thougth she heard something at 4 am but nothing was there. what dementia?
alzheimers
sundowning (pt randomly “hears something” b/c they’re disoriented)
23/30 = early dementia
pt becomes more sad, has alzheimers, her current MMSE is 8/30. she wakes up early, all lab tests are normal. 1st line pharm tx
begin SSRI for depression and monitor status
what to check for lithium
BUN/CR
electrolytes
TFTs
lithium levels
TSH
pregnancy test
pt lost vision after watching her parent’s murder. all exams normal. dx
functional neuro symptom disorder (conversion disorder)
9 week hx low mood, wakes up early, doesn’t sleep, can’t concentrate, recurrent thoughts of death. dx
major depressive disorder
naked in public, said he was president of the bank, never had bipolar depression before. has depression. has bipolar disorder. taking lithium. what to add?
2nd gen/atypical antipsychotic
pt is in manic episode w/ psychotic features
severe manic episode w/ psychotic features first-line tx
mood stabilizer + 2nd gen (atypical) antipsychotic (risperidone)
what to do if alc withdrawal?
gradually reduce high-dose benzo over 5-7+ days with thiamine by injection
s/sx of wernicke’s encephalopathy
opthalmoplegia
nyastagmus
ataxia
confusion
has the thought to stop to get fast food, thinks the thought was “injected” into his mind and that this could be a trap
thought insertion
paranoid PD first-line tx
psychotherapy
igh fever, "lead-pipe" generalized muscle rigidity, altered mental status, and autonomic instability (tachycardia, sweating, labile blood pressure) AND starting a 1st gen antipsychotic (haloperidol) = ?
Neuroleptic Malignant Syndrome (NMS)
discontinue offending agent, supportive care (physical cooling and fluids)
enuresis tx option when non-pharm does not work, and what test do you do
imipramine
TCA (antichol)
you must do EKG before starting d/t risk of heart issues
Korsakoff's Syndrome cause and sx
cause: thiamine (vit b1) def from alcohol use
→ chronic amnesia (anterograde and retrograde) w/ confabulation (making up stories)
wernicke’s encephalopathy triad
confusion
opthalmoplegia
ataxia
schizophrenia first-line tx
2nd gen (atypical) antipsychotics
(risperidone, olanzepine, arpiprazole)
brief psychotic vs. schizophreniform vs. schizophrenia
brief psychotic: <1 month
phreniform: 1-6 month
schizophrenia: >6 mos
Dementia with Lewy Bodies (DLB)
fluctuating cognition
recurrent visual hallucinations
parkinson sx (rigidity, resting tremor, shuffling)
alzheimers 1st sign
anterograde amnesia (short-term memory loss)
antidote for TCA overdose
IV sodium bicarbonate
OCD first-line pharm + non-pharm
exposure and response prevention (CBT)
SSRI
what drug is CI in bulimia and anorexia?
wellbutrin
first-line tx for alcohol withdrawal (delirium tremens)
benzos (lorazepam, diazepam, etc)
MSE components
motor behavior
mood
affect
speech
perceptual disorders (impaired reality)
echolalia definition
repeating what is heard
blocking thought process
long pauses in talking
MMSE - judgement
understanding relationships and drawing conclusion
MMSE - insight
pt realizing there is a problem and needing tx
paranoid PD vs. delusional disorder (persecutory type)
P: NO specific delusional systems (ie refusing to eat food b/c they believe they’re being poisoned)
D: specific delusion thoughts, function is NOT impaired, behavior is not “disorganized”
drug causing nyastagmus + super human strength
dissociative psychedelics (phencyclidine / PCP)
difference in somatic sx vs. illness anxiety disorder
somatic sx disorder: pt is complaining of a sx
illness anxiety disorder: pt is worried about GETTING a disease
refeeding syndrome looks like?
surge in insulin secretion causing intracellular shift →
hypophosphatemia
hypokalemia
volume overload
which drug are you worriedfrom agranulocytosis?
clozapine (2nd gen antipsy)
watch NEUTROPHIL COUNT (ANC)
decreased hypocretin/orexin → ?
narcolepsy type 1
neuroleptic malignant syndrome + tx
rx d/t antipsychotics!
hyperthermia
“lead pipe” muscle rigidity
HTN/tachy
altered mental status
high CK
tx: dantrolene or bromocriptine
acute dystonic reaction + tx
localized, involuntary muscle contraction (ie torticollis)
NO fever, alt mental status
tx: benztropine or benadryl
antipsychotics are good for treating the _ sx of schizophrenia but NOT as good for the what
positive sx
negative sx
naltrexone
good for SUD
CI if liver disease
best FDA-approved med to reduce alc cravings + ok for liver dz
campral
panic disorder first-line tx
SSRI + CBT
what drug withdrawal → seizures?
benzos (alprazolam)
oppositional defiant disorder (ODD) vs. conduct disorder
ODD does not have violation of severe rights
BOTH have irritable mood, defiant behavior, >6 mos
social anxiety first-line tx
propranolol PRN
capgras, fregoli, and cotard delusion
capgras: familiar person replaced by imposter
fregoli: different people are the same person in disguise
cotard: self is rotting or dead
flight of ideas vs. word salad
flight of ideas you can see the shift to the topics (tx is to block the dopamine)
word salad is just a jumbled mess
pt comes in agitated, temp, dilated pupils, clonus, hyperreflexia, and started a new med recently. what is the cause?
SSRI and MAOI
(this is serotonin syndrome)
schizophreniform vs. delusional disorder
schizophreniform >1 month
delusional disorder >1 month and NO hallucinations, NO fx-al impairment, no change in speech, no flat affect, no self-neglect
doctrine of double effect
an action with a foreseeable bad effect (ie quickening death) is ok if the action if intended to achieve good (ie relieve pain)
most common SE of ECT
transient retrograde and anterograde amnesia (taht goes away on its own)
HA, nausea, muscle soreness
Reaction Formation
person transforms an unacceptable, distressing impulse or feeling (here: intense resentment and anger toward his newborn) into its exact opposite (overprotective affection)
Displacement
unacceptable feeling is redirected toward a different, safer target
sleep terrors
occur durning non-REM sleep, 1/3 of night
screaming, difficulty consoling
complete amnesia of event the next day
schizophrenia criteria*
2 or more sx:
delusions (ie “they’re watching my thoughts via wifi”)
disorganized speech (fragmented sentences)
negative sx (ie flat effect, social withdrawal)
disruptive mood dysregulation disorder vs. intermittent explosive disorder
DMDD: 3+ a week
IED is not as often
fragile X syndrome
long face, large ears, macroorchidism
autism-like traits
REM sleep behavior disorder
loss of normal muscle atonia → motor enactment of dreams