IPS1 - [Tablets]- Tablets And Tablet Excipients

Proverbs 16:3

Tablets

These are solid pharmaceutical dosage forms containing drug substances usually prepared with the aid of suitable excipients.

Tablets

These are solid dosage forms that are prepared by MOLDING or COMPRESSION methods.

Molding method

Method of preparation for SOFT tablets.

Compression method

Method of preparation for HARD tablets.

● Wet granulation method

● Dry granulation method

● Direct compression

There are THREE main COMPRESSION techniques for hard tablets:

● Diluents

● Binders

● Disintegrants

● Glidants

● Lubricants

● Colors and dyes

● Flavoring/Sweetening agents

● Tablet coating agents

What are the different TABLET EXCIPIENTS?

Diluents/Fillers

[TABLET EXCIPIENTS]

These are also known as FILLERS; designed to make up the desired bulk, flow properties, and compression.

● Lactose

● Mannitol

● Starch

● Dibasic calcium phosphate

● Sorbitol

● Powdered cellulose

[TABLET EXCIPIENTS]

Examples of DILUENTS/FILLERS

Diluents/Fillers

[TABLET EXCIPIENTS]

● Lactose

● Mannitol

● Starch

● Dibasic calcium phosphate

● Sorbitol

● Powdered cellulose

Binders

[TABLET EXCIPIENTS]

These are used to cause ADHESION of powder particles in tablet granulations.

● Acacia

● Carboxymethyl cellulose (CMC)

● Gelatin

● Methylcellulose (MC)

● Ethylcellulose (EthC)

● Compressible sugar

● Liquid glucose

[TABLET EXCIPIENTS]

Examples of BINDERS

Binders

[TABLET EXCIPIENTS]

● Acacia

● Carboxymethyl cellulose (CMC)

● Gelatin

● Methylcellulose (MC)

● Ethylcellulose (EthC)

● Compressible sugar

● Liquid glucose

Disintegrants

[TABLET EXCIPIENTS]

These are used to promote DISRUPTION of solid mass into smaller particles.

● CMC (Carboxymethyl cellulose)

● CMC Calcium

● Microcrystalline cellulose

● Starches

[TABLET EXCIPIENTS]

Examples of DISINTEGRANTS

Disintegrants

[TABLET EXCIPIENTS]

● CMC (Carboxymethyl cellulose)

● CMC Calcium

● Microcrystalline cellulose

● Starches

Glidants

[TABLET EXCIPIENTS]

These are used to enhance FLOW PROPERTIES of powders.

● Colloidal silica

● Cornstarch

● Talc

[TABLET EXCIPIENTS]

Example of GLIDANTS

Glidants

[TABLET EXCIPIENTS]

● Colloidal silica

● Cornstarch

● Talc

Lubricants

[TABLET EXCIPIENTS]

These are used to reduce FRICTION during tablet compression.

● Calcium stearate

● Magnesium stearate

● Zinc stearate

● Mineral oil

● Stearic acid

[TABLET EXCIPIENTS]

Examples of LUBRICANTS

Lubricants

[TABLET EXCIPIENTS]

● Calcium stearate

● Magnesium stearate

● Zinc stearate

● Mineral oil

● Stearic acid

Colors and Dyes

[TABLET EXCIPIENTS]

These are usually to impart COLOR to the tablet.

FD&C lakes

[TABLET EXCIPIENTS]

Examples of COLORS/DYES

Flavoring/Sweetening agents

[TABLET EXCIPIENTS]

These are usually limited to CHEWABLE and BUCCAL tablets.

Chewable and Buccal tablets

[TABLET EXCIPIENTS]

Flavoring/Sweetening agents are usually limited to ___ and ___ tablets.

● Sugar-coating agents

● Film-coating agents

● Enteric-coating agents

[TABLET EXCIPIENTS]

Types of TABLET COATING AGENTS

● Liquid glucose

● Sucrose

[TABLET EXCIPIENTS]

Examples of SUGAR-COATING AGENTS

Sugar Coating Agents

[TABLET EXCIPIENTS]

● Liquid glucose

● Sucrose

● Methylcellulose (MC)

● Ethylcellulose (EthC)

● Hydroxyethyl cellulose

● Hydroxypropyl cellulose

[TABLET EXCIPIENTS]

Examples of FILM-COATING AGENTS

Film Coating Agents

[TABLET EXCIPIENTS]

● Methylcellulose (MC)

● Ethylcellulose (EthC)

● Hydroxyethyl cellulose

● Hydroxypropyl cellulose

● Cellulose acetate phthalate

● Shellac

[TABLET EXCIPIENTS]

Examples of ENTERIC-COATING AGENTS

Enteric Coating Agents

[TABLET EXCIPIENTS]

● Cellulose acetate phthalate

● Shellac

Shellac

[TABLET EXCIPIENTS]

A 35% solution of ____ in alcohol is commonly used and referred to as "pharmaceutical glaze."

35%

[TABLET EXCIPIENTS]

A ___% solution of shellac in alcohol is commonly used and referred to as "pharmaceutical glaze."

pharmaceutical glaze

[TABLET EXCIPIENTS]

A _35% solution of shellac in alcohol is commonly used and referred to as "____."