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Nature–nurture
The debate over whether traits are inborn (nature) or shaped by experience (nurture).
Behavior genetics
Study of how genes and environment influence behavior.
Mutation
Random DNA replication error introducing genetic variation.
Heredity
Genetic transfer of traits from parents to offspring.
Genome
Complete genetic instructions for making an organism.
Identical twins
One egg splits into two; genetically identical.
Fraternal twins
Two eggs; genetically like normal siblings.
Interaction
When gene effects depend on environment.
Epigenetics
Study of environmental effects on gene expression.
Epigenetic marks
Chemical tags (e.g., methyl) that turn genes on/off.
Heritability
Proportion of variation explained by genes in a group.
Gene–environment
Example: genetic anxiety appears only under stress.
Nervous system
Electrochemical communication network of the body.
CNS
Brain and spinal cord; decision center.
PNS
Sensory and motor neurons connecting CNS to body.
Sensory neurons
Carry incoming info to CNS.
Motor neurons
Send outgoing instructions from CNS.
Interneurons
Communicate within CNS between sensory and motor.
Somatic NS
Controls voluntary skeletal muscles.
Autonomic NS
Controls glands and internal organs automatically.
Sympathetic NS
Arouses body for “fight or flight.”
Parasympathetic NS
Calms body after stress (“rest and digest”).
Homeostasis
Body’s tendency to maintain internal balance.
Neuron
Basic nerve cell; dendrites, soma, axon.
Myelin sheath
Fatty layer speeding neural impulses; damage = MS.
Glial cells
Support, nourish, and protect neurons.
Action potential
Electrical impulse traveling down axon.
Resting potential
Negative charge when neuron inactive (~–70 mV).
Threshold
Stimulation level required to trigger firing.
Depolarization
Na⁺ ions enter; inside becomes positive.
Repolarization
Positive ions exit; charge returns negative.
Excitatory signal
Increases chance neuron will fire.
Inhibitory signal
Decreases chance neuron will fire.
Refractory period
Time after firing when neuron cannot fire again.
All-or-none
Neuron fires completely or not at all.
Synapse
Gap between neurons where signals cross.
Reuptake
Reabsorption of neurotransmitters by sending neuron.
Axon terminal
Releases neurotransmitters into synaptic gap.
Neurotransmitters
Chemical messengers crossing synapses.
Acetylcholine
Muscle action, learning, memory; low = Alzheimer’s.
Myasthenia gravis
Immune attack on ACh sites → muscle weakness.
Dopamine
Motion, learning, emotion; high = schizophrenia, low = Parkinson’s.
Serotonin
Mood, hunger, sleep; low = depression.
Norepinephrine
Arousal, alertness; imbalance → anxiety/depression.
GABA
Main inhibitory transmitter; low = seizures/insomnia.
Glutamate
Main excitatory transmitter; excess = migraines/seizures.
Endorphins
Natural painkillers; opiates suppress production.
Substance P
Transmits pain signals; more = higher pain.
Adenosine
Promotes sleep; caffeine blocks its receptors.
Oxytocin
Bonding and trust hormone; released during affection.
Vasopressin
Regulates water and social bonding/aggression.
Histamine
Arousal and immune response; antihistamines cause drowsiness.
Melatonin
Pineal hormone controlling sleep–wake cycle.
Agonist
Mimics or enhances neurotransmitter effect.
Antagonist
Blocks neurotransmitter action at receptor sites.
Neuromodulator
Chemical altering neurotransmitter release/sensitivity.
LTP
Long-term strengthening of synapses; basis of learning.
Endocrine system
Chemical communication via hormones in blood.
Hormones
Chemical messengers affecting distant organs.
Pituitary gland
“Master gland”; releases growth hormone, controls others.
Hypothalamus
Links nervous and endocrine systems; regulates drives.
Thyroid
Controls metabolism.
Parathyroid
Regulates calcium levels.
Adrenal glands
Release epinephrine/norepinephrine for stress.
Pancreas
Controls blood sugar with insulin and glucagon.
Gonads
Produce sex hormones (testosterone, estrogen).
Pineal gland
Secretes melatonin for sleep.
HPA axis
Stress-response loop (hypothalamus–pituitary–adrenal).
Feedback loop
Hypothalamus → pituitary → glands → hormones → brain.
Psychoactive drugs
Chemicals altering perception, mood, behavior.
Tolerance
Needing larger dose for same effect.
Withdrawal
Discomfort after stopping drug use.
Depressants
Slow neural activity (alcohol, barbiturates, opiates).
Stimulants
Excite neural activity (caffeine, nicotine, cocaine, meth).
Hallucinogens
Alter perception (LSD, THC, psilocybin).
Alcohol
Enhances GABA/dopamine; impairs memory, control.
Barbiturates
Reduce anxiety but impair coordination; overdose risk.
Opiates
Mimic endorphins; relieve pain, cause euphoria.
Amphetamines
Increase dopamine; high energy, then crash.
Cocaine
Blocks dopamine/serotonin reuptake; brief euphoria.
Caffeine
Blocks adenosine; increases alertness.
Nicotine
Stimulates dopamine/norepinephrine; addictive.
LSD
Mimics serotonin; vivid hallucinations.
THC
Activates cannabinoid receptors; slows reactions.
Reward pathway
Dopamine circuit (VTA → nucleus accumbens → cortex).
EEG
Measures brain waves (electrical activity).
MEG
Measures magnetic fields from neural firing.
CT scan
X-ray images showing brain structure.
PET scan
Measures glucose use → activity.
MRI
Shows detailed brain structure.
fMRI
Shows blood flow → structure + function.
Structure vs function
CT/MRI = structure; EEG/MEG/PET/fMRI = function.
Hindbrain
Breathing, heartbeat, balance (medulla, pons, cerebellum).
Midbrain
Relays sensory info; coordinates movement.
Forebrain
Higher thought and emotion (limbic system, cortex).
Brainstem
Oldest part; automatic survival functions.
Medulla
Controls heartbeat and breathing.
Pons
Coordinates movement and sleep.
Reticular formation
Arousal and alertness; damage = coma.
Thalamus
Sensory relay (except smell) to cortex.