Key Drug Quiz 2

IcyHot (menthol 10%, methyl salicylate 30%)

- MOA: provides paradoxical pain relief through producing a less-severe pain stimulation to counter a more severe one
- Duration: Relief may last up to 6-8 hours
- Dose: Apply thin layer to affected area 3-4 times daily
- Side effects: skin irritation, rash
- Not for use under 12 years old

Voltaren (diclofenac)

- MOA: block synthesis of prostaglandins in both central and peripheral nervous system (NSAID)
- Onset: 30 minutes
- Duration: Relief may last up to 6 hours
- Dose:
*Adult: Dosing card provides volume based on body part. Use appropriate amount up to 4 times daily (max 16g for one joint, max 32g for all joints daily)
- Side effects: rare due to lower systemic absorption (upset stomach, nausea)

Bayer Aspirin (aspirin)

- MOA: irreversible inhibition of prostaglandin synthesis of both COX-1 and COX-2 enzymes (NSAID)
- Onset: 30 minutes
- Duration: Relief may last up to 6-8 hours
- Dose:
*For Pain: 325-1000mg every 4-6 hours as needed (max 1200mg daily)
- Side effects: nausea, vomiting, bleeding, upset stomach

naproxen, NSAIDs, synthesis, 8, 660, 12, nausea, ulceration, headache

Aleve, generic: — Therapeutic Class: —

- MOA: block — of prostaglandins in both central and peripheral nervous system
- Onset: 30 minutes
- Duration: Relief may last up to 6-# hours
- Dose: 220mg every 8-12 hours as needed (max #mg daily)
*NOT FOR THOSE <# years old
- Side effects: upset stomach, —, GI — with long-term use, fluid retention, —, dizziness, renal impairment

Motrin, Advil, NSAID, 1200, 6 months, epigastric, food, GI, hydration, 8, 2, ulcers, 3rd,

Ibuprofen, brands: —, — Class: —
- MOA: block synthesis of prostaglandins in both central and peripheral nervous system
- Onset: 30 minutes
- Duration: Relief may last up to 6-8 hours
- Dose:
*Adult: 200-400mg every 4-6 hours as needed (max #mg daily)
*>/= # —: 5-10mg/kg every 6-8 hours (1200mg daily)
- Side effects: upset stomach, nausea, GI ulceration with long-term use, — gas, renal impairment, fluid retention

Counseling: take with — to reduce — upset, take the lowest effective dose for the shortest amount of time, maintain —, may blunt cardioprotective asprin → take ibuprofen # hours before or asprin # hours after

Refer if: history of --, heart failure, avoid in — trimester pregnancy or if pain lasts >10 days or fever >3 days

Tylenol, analgesic/antipyretic, CNS, 4, 325, 1000, 2400, hepatotoxicity, alcohol, pregnancy

Acetaminophen, brand: —, Class: —/— [has no anti-inflammatory properties]

- MOA: mechanism for pain relief unclear; may inhibit prostaglandin synthesis in —
- Onset: 30 minutes
- Duration: Relief may last up to # hours (6-8 with extended formulation)
- Dose:
*Adult: IR # to # mg every 4-6 hours as needed (max 4000mg daily); ER 650-1300mg every 8 hours as needed
*Children: <12 y/o: 10-15mg/kg every 4-6 hours (# mg daily)
- Side effects: nausea, —, rash (rare)

Counseling: only take 1 type of acetaminophen at once (risk of OD), limit/avoid —, preferred in — or GI sensitive patients, has no meaningful anti-inflammatory effect

Tylenol

Acetaminophen (APAP)

ibuprofen

motrin or advil

Aleve

Naproxen

asprin

Ecotrin or Bayer

voltaren

diclofenac

IcyHot OG

Menthol 10%, Methyl Salicylate 30%

NSAID

Ibuprofen and Naproxen are the drug class —

analgesic, antipyretic

acetaminophen is an — and an —

topical

voltaren is a — analgesic

counterirritant

IcyHot is a — analgesic

NSAID

asprin is from the — drug class, but it also has antiplatelet effects