Epinephrine: Pharmacology, Dosing, and Clinical Use in Emergency Medicine

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Last updated 12:43 AM on 5/3/26
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13 Terms

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Class

Sympathomimetic

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Schedule

S3 (IM), S4 (IV/IO)

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Mechanism of Action

α1 → vasoconstriction ↑ BP; β1 → ↑ HR & contractility; β2 → bronchodilation

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Cardiac arrest adult dose

1 mg IV/IO (1:10,000) every 3-5 min

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Anaphylaxis adult dose

0.5 mg IM (1:1,000), repeat every 5 min PRN

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Severe asthma adult dose

0.5 mg IM

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Contraindications

None in life-threatening situations

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Precautions

Cardiac disease, hypertension; Elderly; Risk of arrhythmias

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Onset

IM: 3-5 min | IV: immediate

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Duration

5-10 min

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Half-life

2-3 min

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Presentation

1:1,000 ampoule; 1:10,000 prefilled syringe

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Key Points

Short half-life → repeat dosing essential; IM = lateral thigh; High-risk medication → dose errors common