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helicase
breaks hydrogen bonds, unwinding DNA double helix
primase
synthesizes RNA primers on leading and lagging strands
DNA polymerase I
replaces RNA primers with DNA nucleotides
DNA ligase
catalyzes phosphodiester bond formation, joining DNA fragments
topoisomerase
relaxes supercoiled DNA
single stranded binding proteins
coat single-stranded DNA
DNA polymerase III
synthesizes DNA 5’ to 3’ on leading and lagging strands