[PCOL-FIN-01-PT3] ANTIPSYCHOTICS

THIS FLASHCARDS IS ABOUT [PCOL] MOA OF ANTIPSYCHOTICS.

• Neuroleptics

• Major tranquilizer

Antipsychotics is also known as (2)?

D₂-receptors-blockers

General MOA of Antipsychotics:

Targets the dopamine-2- receptors and are generally called the?

Mesolimbic pathway

D₂ is more pronounced in which pathway?

Serotonin (5-HT)

Some clinical studies shows that schizophrenia is not only because of dopamine but also?; because this monoamine neurotransmitter induces hallucination and delusion if activated.

Lysergic acid diethylamide (LSD)

This drug is a 5-HT agonist.

(Serotonin activity is increased)

• Lysergic acid diethylamide (LSD)

• Mescaline

These drugs are serotonin receptor activators causing hallucinations and delusions (5-HT agonist).

Hint: LSD-Mes

Info

In some theories, when (-) 5-HT is blocked, dopamine in limbic region is decreased which is an advantage against schizophrenia.

• D2

• D1

• D4

What dopamine receptors are mostly (pronounced) found in the CNS?

D2

Which dopamine receptors is the only much related in psychosis?

Info

In general MOA of antipsychotics (D₂ blockers), it targets the D₂ receptors.

• 1st generation (Typicals)

• 2nd generation (Atypicals)

Antipsychotics are classified into two generations called?

• Phenothiazines

• Butyrophenones

• Thioxanthenes

What are the (3) 1st Generation/Typical Antipsychotics?

Hint: PBT

Chemical structures

1st Generation/Typical Antipsychotics are classified based on chemistry or its?

• Aliphatic

• Piperidine

• Piperazine

What are the (3) Side Chains of Phenothiazines (1st Generation/Typicals)?

Hint: APP

-promazine

1st Generation Phenothiazines with Aliphatic side chain usually ends with the suffix?

• Chlorpromazine

• Triflupromazine

• Levomepromazine

What are the (3) Drugs under Phenothiazines with Aliphatic side chain (1st Generation/Typicals)?

Hint: CTL-promazine

-azine

1st Generation Phenothiazines with Piperidine side chain usually ends with the suffix?

• Thioridazine

• Mesoridazine

• Pericyazine

• Pipotiazine

What are the (4) Drugs under Phenothiazines with Piperidine side chain (1st Generation/Typicals)?

Hint: TMPP-azine

-nazine

1st Generation Phenothiazines with Piperazine side chain usually ends with the suffix?

• Trifluoperazine

• Fluphenazine

• Perphenazine

What are the (3) Drugs under Phenothiazines with Piperazine side chain (1st Generation/Typicals)?

Hint: TFP-azine

-peridol

1st Generation Phenothiazines (Butyrophenones) usually ends with the suffix?

• Haloperidol

• Bromperidol

• Droperidol

• Benperidol

• Trifluperidol

• Penfluridol

What are the (6) Drugs under Phenothiazines: Butyrophenones (1st Generation/Typicals)?

Hint: HBD-BTP-peridol

-th-

1st Generation Phenothiazines (Thioxanthenes) has this two letters in their names.

• Flupenthixol

• Clopenthixol

• Thiothixene

• Chlorprothixene

What are the (4) Drugs under Phenothiazines: Thioxanthenes (1st Generation/Typicals)?

Hint: FC-TC