Quality Control (Red)

C. Graduated cylinder

Acceptable glassware to be used to deliver an exact volume of a certain standard solution to be used for titration:

A. Beaker

B. Buret

C. Graduated cylinder

D. Analytical balance

E. Volumetric flask

C. Type 316

An inert type of stainless steel used in dissolution

apparatus recognized by the USP:

A. Type 114

B. Type 239

C. Type 316

D. Type 489

E. All of the choices

D. Volumetric flask

Volumetric apparatus designed to contain a definite

volume of liquid:

A. Beaker

B. Buret

C. Pipet

D. Volumetric flask

E. B and C

E. Sodium Methoxide VS

Titrant employed for non-aqueous alkalimetric titration:

A. Ammonium Hydroxide

B. Hydrochloric Acid VS

C. Perchloric Acid in Glacial Acetic Acid VS

D. Potassium Hydroxide VS

E. Sodium Methoxide VS

D. Potassium Biphthalate

USP specifies that the standardization of Sodium Hydroxide VS should be done using ______ as standard:

A. Hydrochloric Acid VS

B. Sodium Carbonate

C. Tromethamine

D. Potassium Biphthalate

E. Potassium Dichromate

E. Assay of Sulfurated Potash, USP

6. Gravimetric analysis is an appropriate method for:

A. Determination of Atropine content of Belladonna leaf

B. Assay of Sodium Chloride, USP

C. Assay of Zinc Chloride, USP

D. Assay of Sodium Nitrite, USP

E. Assay of Sulfurated Potash, USP

B. Ferric Ammonium Sulfate TS

Volhard Method in volumetric precipitation involves

the use of what indicator?

A. Eosin TS

B. Ferric Ammonium Sulfate TS

C. Phenolphthalein TS

D. Potassium Chromate TS

E. Orthophenanthroline TS

C. Kjeldahl method

Nitrogen content determination of foods and

pharmaceuticals involves what method?

A. Fajan's method

B. Gay-Lussac method

C. Kjeldahl method

D. Gravimetric method

E. Winkler method

D. Iodine number

Fat constant that states the degree of unsaturation

in fats and fixed oils:

A. Polenske number

B. Koettsdorfer number

C. Unsaponifiable matter

D. Iodine number

E. Acetyl number

C. Maxima or minima of the plot

In potentiometric titration, the equivalence point in

the first derivative plot is signified by:

A. The steepest part of the curve

B. The line that crosses 0 in the x axis

C. Maxima or minima of the plot

D. Sharp change in pH reading

E. Change in color of the solution

E. Friabilator

An instrument that measures the durability of

tablets to withstand shock and abrasion during

transport:

A. Hardness tester

B. Caliper

C. Analytical balance

D. Polarimeter

E. Friabilator

B. A quantity of not exceeding 0.50 mg

USP definition of negligible:

A. A quantity of not exceeding 0.25 mg

B. A quantity of not exceeding 0.50 mg

C. A quantity of not exceeding 2.5 mg

D. A quantity of not exceeding 5.0 mg

E. None of the choices

A. Cod liver oil

An example of drying oil:

A. Cod liver oil D. Sesame oil

B. Olive oil E. Lard

C. Coconut oil

C. Red to blue

Orthophenanthroline TS undergoes a color

transition from ______ to ______:

A. Colorless to pink D. White to black

B. Yellow to red E. Blue to yellow

C. Red to blue

A. Desiccator

A tightly closed container of suitable size and

design that maintains an atmosphere of low moisture

content by means of appropriate drying agents:

A. Desiccator

B. Muffle furnace

C. Oven

D. Glass stoppered bottle

D. Soxhlet apparatus

Apparatus used for determination of alcoholsoluble extractives of benzoin:

A. Acetylization flask

B. Cassia flask

C. Babcock bottle

D. Soxhlet apparatus

E. Clavenger apparatus

D. 1.3337

Calculate the normality factor for 0.1N Sodium Thiosulfate VS given the following data:

Weight of Potassium Dichromate=0.2256g

Volume of titrant consumed during standardization=34.55mL

Volume of titrant consumed during blank determination=0.05mL

Molecular Weight of Sodium Thiosulfate=248.19g/mol

Molecular Weight of PotassiumDichromate=294.18g/mol

A. 1.5801

B. 0.2635

C. 0.6669

D. 1.3337

E. 1.8153

E. Dichlorophenol-Indophenol VS

Titrant used for the official assay of ascorbic acid dosage forms:

A. Sodium Tetraphenylboron VS

B. Iodine VS

C. Potassium Hydroxide VS

D. Disodium Edelate VS

E. Dichlorophenol-Indophenol VS

C. 5

Equivalence factor for potassium permanganate

as an oxidizing agent:

A. 2

B. 3

C. 5

D.10

E. 23

B. Caraway oil

Assay of volatile oil which involves bisulfate addition method:

A. Olive oil

B. Caraway oil

C. Lemon oil

D. Peppermint spirit

E. Clove oil

C. Gooch Crucible

A glassware usually used in gravimetric analysis

that has a perforated bottom upon which is bedded of

asbestos that is used for separation of precipitates by

use of suction filtration:

A. Aspirator

B. Buchner funnel

C. Gooch Crucible

D. Soxhlet apparatus

E. Reflux condenser

C. 0.20-0.25%

For samples which contain 50-100% of the active constituent, the difference in percent between two determinations should be:

A. 0.03-0.05%

B. 0.10-0.20%

C. 0.20-0.25%

D. 0.30-0.45%

E. Not more than 3%

D. Chromic acid

In analytical chemistry, cleaning solution is basically a solution containing:

A. Nitric acid

B. Joy®

C. Sodium phosphate

D. Chromic acid

E. Liquid Sosa®

B. CH3COOH-CH3COONa buffer

pH-adjusting agent used in EDTA titrations using Dithizone TS as indicator:

A. 3N HCL

B. CH3COOH-CH3COONa buffer

C. NH3-NH4Cl buffer

D. 1N NaOH

E. Any of the choices

D. Yellow

Acid color of phenol red:

A. Colorless

B. Red

C. Blue

D. Yellow

E. Green

C. Sodium Thiosulfate VS

Reducing titrant that is susceptible to bacterial degradation:

A. Oxalic Acid VS

B. Potassium Permanganate VS

C. Sodium Thiosulfate VS

D. Ferrous Ammonium Sulfate VS

E. Ceric Sulfate VS

B. Intense purple color of permanganate ion

C. Blue color of starch-iodo complex

(duwa ang naka highlight sa choices)

Actual indicating species in the assay of Hydrogen Peroxide Topical Solution:

A. Free iodine extracted by chloroform

B. Intense purple color of permanganate ion

C. Blue color of starch-iodo complex

D. Use of Diphenylamine TS as indicator

E. None of the choices

B. Policeman

A piece of soft rubber tubing fitted to the end of a glass rod. It is used to loosen from the walls of the containing vessel adhering particles that are not removable by a stream of water from the wash bottle:

A. Erlenmeyer flask

B. Policeman

C. Spatula

D. stirring rod

E. Watchglass

A. Determination of total alkalinity of NaOH

Assay involves an acidimetric type of titration:

A. Determination of total alkalinity of NaOH

B. Phosphomolybdate assay for phosphates

C. Assay of Precipitated Sulfur using oxygen flask combustion

D. Assay of Cupric Sulfate

E. Assay of Zinc Chloride

D. Separatory funnel

Extraction of alkaloids could be done by using:

A. Clavenger apparatus

B. HPLC

C. Brine shrimp assay

D. Separatory funnel

E. Spectrophotometer

A. Arrhenius equation

Stability projection for shelf life of pharmaceuticals are commonly based on ______ equation:

A. Arrhenius equation

B. Clausius-Clapeyron equation

C. Dieterici equation

D. Henderson-Hasselbalch equation

E. Van Deemter equation

D. Spectral absorbance curve

A plot of the absorbance of the analyte vs. wavelength which determines the λmax at which the absorbance of the standard and unknown solutions will be made:

A. Beer's plot

B. Planck's constant

C. Rf value

D. Spectral absorbance curve

E. None of the choices

C. Geiger-Muller Counter

A suitable detector for radioactive samples:

A. UV detector

B. Echelette grating

C. Geiger-Muller Counter

D. Vanillin reagent

E. Iodine vapour

C. Porcelain

Type of crucible that can withstand high temperature and is suitable for use in ignition of drugs and precipitates:

A. Borosilicate Glass

B. Sintered crucible

C. Porcelain

D. B and C

E. A, B and C

B. Glycerol

In the official assay, Boric Acid, NF acts as a strong monobasic acid due to the addition of what sugar alcohol:

A. Erythritol

B. Glycerol

C. Mannitol

D. Sorbitol

E. Xylitol

A. Acid Value

Measures the free fatty acid present in a given sample of fats of fixed oil:

A. Acid Value

B. Ester Value

C. Crude Fiber

D. Iodine Value

E. Unsaponifiable Matter

C. Iodometry

Assay method for Sodium Hypochlorite Solution, USP:

A. Acidimetry

B. EDTA titration

C. Iodometry

D. Permanganometry

E. Volumetric precipitation

E. A, B and C

Official method of water content determination of pharmaceutical samples:

A. Azeotropic distillation

B. Gravimetric determination

C. Karl Fischer method

D. A and C

E. A, B and C

D. 2-Phenoxyethanol

Analyte that involves an alkalimetric type of assay:

A. Magnesium Sulfate

B. Sodium Chloride

C. Hydrogen Peroxide Solution

D. 2-Phenoxyethanol

E. Selenium Sulfide

B. Glass electrode

Most popular indicator electrode for pH determinations that involves the exchange of hydrogen ions on its surface:

A. Standard Hydrogen Electrode

B. Glass electrode

C. Fluoride electrode

D. Quinhydrone electrode

E. Calomel electrode

C. Mohr Method

The use of potassium chromate TS as indicator in Volumetric precipitation is also known as the ______ method:

A. Fajan's Method

B. Gay-Lussac Method

C. Mohr Method

D. Dumas Method

E. Volhard Method

D. Valser's reagent

An aqueous solution composed of potassium iodide and red mercuric iodide used for the detection of alkaloids:

A. Dragendorff's reagent

B. Hubl's reagent

C. Mayer's reagent

D. Valser's reagent

E. Wagner's reagent

D. Dissolution

The reciprocating cylinder, basket apparatus and paddle apparatus are used for what in-vitro test for tablets?

A. Assay

B. Content Uniformity

C. Disintegration

D. Dissolution

E. Friability

C. More than 324 mg

In weight variation test for tablets, a 5.0% difference in average tablet weight is accepted for tablets with an average weight of:

A. 130 mg or less

B. 130 mg to 324 mg

C. More than 324 mg

D. A and B

E. A, B and C

B. II and III

In what case/s will addition of nitrobenzene be unnecessary in Volhard analysis?

I. Determination of chloride

II. Determination of bromide

III. Determination of iodide

A. I only

B. II and III

C. I and II

D. III only

E. I, II and III

D. 2.5mg/g

Solve for the acid number of a 2g sample of cod liver oil which required 4.5mL of 0.02 KOH in the titration.(MW of KOH 56.11g/mol):

A. 0.25%

B. 2.5%

C. 25mg/g

D. 2.5mg/g

E. 0.25mg/g

B. Sulfonamides

Diazotization assay is used for analysis of what class of analytes?

A. Mercaptans

B. Sulfonamides

C. Alkaloids

D. Cyanides

E. Volatile oils

D. Polarimeter

Optical rotation is measured using what instrument?

A. Refractometer

B. ph meter

C. HPLC

D. Polarimeter

E. Spectrophotometer

C. Triethanolamine

Masking agent that permits the determination of Mg+2 in the presence of Al+3 ions:

A. Absolute alcohol

B. Ammonium Fluoride

C. Triethanolamine

D. Potassium Sodium Tartrate

E. Nitric acid

D. Content Uniformity

A parameter that checks the homogeneity of the active ingredient in tablets and is usually done by assaying a certain number of tablets individually:

A. tablet hardness

B. Tablet thickness E. Weight variation

C. Dissolution

D. Content Uniformity

E. Weight variation

B. Promote formation of a brown precipitate

Insufficient sulphuric acid added to the analyte solution during permanganate titration will:

A. Will turn the solution intense purple

B. Promote formation of a brown precipitate

C. Will discharge the color of permanganate ion

D. Promote completion of the reaction

E. Will turn the solution green

B. 4.6

EDTA titration using dithizone TS as indicator should be conducted at what pH?

A. 2

B. 4.6

C. 7

D. 10

E. 13

B. 37.85%

The water content of an 875.4mg samle of dried

neem leaves was determined with a moisture

analyzer. What is the % w/w H2o in the leaves if the

final mass was found to be 545.8mg?

A 1.60%

B. 37.85%

C. 62.35%

D. 98.40%

E. 5.42%

D. Loss on ignition

This value represents the percentage of test material which is volatilized and driven off under the condition specified:

A. Water content Determination

B. Ignition to constant weight

C. Loss on drying

D. Loss on ignition

E. Acid insoluble ash

B. Sodium Hydroxide VS

Potassium biphthalate is a primary standard used for standardization of ______:

A. Sulfuric Acid VS

B. Sodium Hydroxide VS

C. Ammonium Thiocyanate VS

D. Potassium Permanganate VS

E. Disodium Edetate VS

D. Reversed-phase chromatography

Type of chromatography wherein the mobile phase is polar in nature and the stationary phase is nonpolar in nature:

A. Thin layer chromatography

B. Ion-exchange chromatography

C. Normal phase chromatography

D. Reversed-phase chromatography

E. Paper chromatography

C. Sulfuric Acid VS

Tromethamine is a primary standard used for the standardization of what VS?

A. Sodium Nitrite VS

B. Ammonium Thicyanate VS

C. Sulfuric Acid VS

D. Silver Nitrate VS

E. Perchloric Acid VS

D. Water

Stationary phase in paper chromatography:

A. Cellulose

B. Acetic acid

C. Acetonitrile

D. Water

E. Methanol

E. All of the choices

Method of detection for TLC:

A. Iodine vapour

B. Sulfuric acid

C. UV lamp

D. Vanillin Reagent

E. All of the choices

C. Gypsum

What does G stand for in silica gel G?

A. Gauss

B. Germanium

C. Gypsum

D. Gall

E. Ghrelin

B. To permit dissolution of iodine in water

Purpose of potassium iodide in preparation of Iodine VS:

A. To protect iodine from microbial degradation

B. To permit dissolution of iodine in water

C. As an Antioxidant

D. A and B

E. A, B and C

D. Sugar alcohol

Iodometry is a suitable method for:

A. Ascorbic acid

B. Mercaptans

C. Sulfites

D. Sugar alcohol

E. Antimony K Tartrate

D. A and B

Suitable form of starch for the preparation of Strach TS:

A. Arrowroot starch

B. Soluble Starch

C. Starch with high α-amylose content

D. A and B

E. A, B and C

C. Sodium carbonate

Reagent added during preparation of Sodium Thiosulfate VS that imparts stability to the volumetric solution by acting as an antimicrobial preservative and suppresses acid-catalyzed hydrolysis of the volumetric solution:

A. Hydrochloric acid

B. Sodium bicarbonate

C. Sodium carbonate

D. Carbon tetrachloride

E. Starch

C. Iodine VS

Volumetric solution that is used for analysis of vitamin C raw material according to USP:

A. Potassium Arsenite VS

B. Sodium Nitrite VS

C. Iodine VS

D. Dichlorophenol-indophenol VS

E. Ceric Sulfate VS

B. Red mercuric iodide

Preservative in Starch TS:

A. Sodium thiosufate

B. Red mercuric iodide

C. Saliva

D. Carbon disulfide

E. Arsenic trioxide

D. hydrochloric acid VS

Titrant which involves the formation of iodine monochloride during titration:

A. Iodine VS

B. Perchloric acid Vs

C. Potassium iodate VS

D. hydrochloric acid VS

E. Sodium Thiosulfate VS

A. 0.1N Bromine VS

Koppeschaar's Solution:

A. 0.1N Bromine VS

B. Chlorine Water

C. 0.1N Iodine VS

D. Phosphoric Acid

E. Ammonium Phosphomolybdate TS

B. 86.99%

A 1.4500g sample of liquefied phenol was

dissolved in enough water to make 1000mL. A 30mL

sample of the solution was treated with 30mL of 0.1 N

Bromine Vs and HCL. The mixture was treated with

potassium iodide and titrated with 7.38mL of 0.1N

sodium Thiosulfate VS. It was also found that 21mL of

0.1N Sodium thiosulfate VS was required in the

titration of the iodine liberated when 20mL of 0.1N

bromine VS was treated with KI and HCL. Calculate

the % phenol in the sample. (MW phenol=94.11g/mol)

A. 29.00%

B. 86.99%

C. 8.70%

D. 65.56%

E. 13.33%

A. 0.40

What is the pH of a 0.400M HNO3 solution?

A. 0.40

B. 2.05

C. 0.60

D. 4.12

E. 1.67

B.8.82%

calculate the NaHCO3 content of a 1.2500g

sample of a mixture containing sodium carbonate and

sodium bicarbonate requiring 13.80mL of 0.5250N

HCL on titration to phenolphthalein endpoint and an

additional 16.30mL on further titration to a methyl

orange endpoint.(MW NaHCO3=84.01g/mol)

A. 61.4%

B.8.82%

C. 17.64%

D. 30.7%

E. 70.22%

C. Nuclear Magnetic Resonance

When organic compound is placed on a very high

magnetic field, the protons absorb radiant energy and

produce characteristics peaks due to the organic

groups associated with the protons:

A. UV spectrophotometry

B. Colorimetry

C. Nuclear Magnetic Resonance

D. HPLC

E. Polarography

A. Hanus method

Method in Iodine Value determination which employs the use of Iodobromide Ts as source of iodine:

A. Hanus method

B. Hubl's method

C. Wij's method

D. Karl Fischer method

E. Winkler method

B. Eluotropic series

A polarity scale of solvent arranged according to increasing eluting power:

A. Electromotive series

B. Eluotropic series

C. Irving-Williams scale

D. pH scale

E. Partition coefficient

C. Ultimate Assay

The assay of Opium for % Morphine content is an example of:

A. Limit Test

B. Trace Constituent Analysis

C. Ultimate Assay

D. Identification Test

E. Proximate Assay

A. 6.87%

An unknown sample of a soluble sulphate weighing 1.8000g yielded 0.9000g of barium sulphate. Calculate the % sulfur present in the unknown. (MW of barium sulfate=233.40g/mol, MW of sulfur=32.06g/mol).

A. 6.87%

B.7.28%

C. 13.74%

D. 3.43%

E. 14.56%

D. 7.44

The acid value of a certain fixed oil is .96 and the ester value is 2.48. What is the saponification number of the sample?

A. 0.50

B. 2.48

C. 3.72

D. 7.44

E. 12.30

C. Phytosterol

Unsaponifiable matter in the plant matter may represent:

A. Unsaturated fatty acid

B. Paraffin

C. Phytosterol

D. Silica

E. Rancidity

A. Acetyl value

Alcoholic hydroxyl groups present in fatty acids is estimated using what fat constant?

A. Acetyl value

B. Acid value

C. Unsaponifiable matter

D. Iodine value

E. Ester value

A. alkalimetric determination of esters

Assay which involves back titration:

A. alkalimetric determination of esters

B. Total alkalinity of fixed alkalis

C. Determination of chloride by fajan's method

D. EDTA titration of zinc ion

E. Determination of peroxide by permanganate method

E. All of the choices

An example of drying agent used in desiccators:

A. Anhydrous calcium chloride

B. Solid potassium hydroxide

C. Phosphorus pentoxide

D. Silica gel

E. All of the choices

D. Iodine flask

Appropriate glassware to be used in the assay of cupric sulfate, USP:

A. Beaker

B. Buret

C. Erlenmeyer flask

D. Iodine flask

E. Volumetric flask

C. Standard deviation

Reproducibility of data within a series of results is usually reported as:

A. Absolute error

B. Relative error

C. Standard deviation

D. t-test

E. Q-test

A. Phenolphthalein

Appropriate indicator for a strong acid-weak base titration:

A. Phenolphthalein

B. Methyl red

C. Eriochrome black T

D. Diphenylamine

E. Starch

B. Leveling

Several acids, dissolved in a solvent, are completely ionized. The solvent can be classified as a ______ solvent:

A. Differentiating

B. Leveling

C. Protogenic

D. Protophilic

E. Aprotic

C. Sodium Fluoride

Analyte that is can be assayed by ferric chloride titration:

A. Antimony potassium tartrate

B. Precipitated sulfur

C. Sodium Fluoride

D. Titanium Dioxide

E. Vanadyl Sulfate

E. A, B and C

Assayed by iodimetry:

A. Iodine Tincture for Iodine Content

B. Sodium Thioglycollate

C. sodium metabisulfite

D. A and B

E. A, B and C

D. 4

Equivalence factor when arsenic trioxide is used for standardization of iodine VS:

A. 1

B. 2

C. 3

D. 4

E. 5

B. Potassium periodate

Titrations involving oxidation of sugar alcohols

involve the use of what oxidizing agent?

A. Ammonium thiocyanate

B. Potassium periodate

C. Potassium permanganate

D. Oxalic acid

E. Sodium thiosulfate

A. Cerimetry

Titrimetric assay for ferrous salts employ what method?

A. Cerimetry

B. Acidimetry

C. Iodometry

D. Precipitimetry

E. Gravimetry

A. 1

Equivalence factor for sodium thiosulfate:

A. 1

B. 2

C. 3

D. 6

E. 10

D. A and B

Determination of bulk density of a power can be done using:

A. Scott volumeter

B. Graduated cylinder

C. Viscometer

D. A and B

E. A, B and C

A. cherry juice for malic acid

Assayed by precipitation as calcium oxalate, conversion to oxalic acid and titrating with acidified permanganate:

A. cherry juice for malic acid

B. sodium nitrite

C. titanium dioxide

D. Selenium sulfide

E. hydrogen peroxide topical solution

B. Ededate ion

Formes a chelate with divalent and multivalent cations:

A. Ammonia

B. Ededate ion

C. Fluoride ion

D. Oxalate ion

E. All of the choices

B. Nernst's law

Extrction using two immiscible solvents using a separatory funnel is governed by _______:

A. Le Chatelier's principle

B. Nernst's law

C. Rf value

D. common-ion effect

E. Law of entropy

C. Oxine

Organic precipitant employed for the assay for MgO content of magnesium citrate oral solution:

A. Cupferron

B. Nitron

C. Oxine

D. DMG

E. Ferroin

A. Accuracy

A parameter that denotes the nearness of the experimental dta of the true value:

A. Accuracy

B. Deviation between trials

C. Precision

D. Ruggedness

E. B and C

E. All of the choices

Chromatography is useful for:

A. Resolution of mixtures into constituents parts

B. ID test by comparing the unknown to a standard

C. Determination of homogeneity

D. Indication of molecular structure

E. All of the choices

D. scissoring and rocking

Examples of in-plane bending vibration of atoms:

A. Scissoring and twisting

B. Rocking and wagging

C. Wagging and twisting

D. scissoring and rocking

E. All of the items mentioned

D. Dropper bottle

Appropriate weighing vessel for liquid samples:

A. Beaker

B. Weighing bottle

C. Watchglass

D. Dropper bottle

E. Volumetric flask