Studied by 13 people
Where are nucleotides added to on the new strand
3’ end
Where does replication begin
Origin of replication (dumbass)
What is a replication forks
the points where a DNA molecule is replicating
What unwinds the DNA strands
DNA helicase
What is synthesized by primase?
Primer (obviously)
What is DNA polymerase
enzyme ha catalyzes the polymerization of nucleotides
What does the leading strand do
grow quickly at the 3’ end
What does the lagging strand do
grows slowly and in pieces because it’s backwards
What are okazaki fragments
small discontinuous stretches of DNA
How is DNA synthesized
From 5’ to 3’
How are okazaki fragments joined together
DNA ligase
What is the replication complex
replication enzymes working together
True or false: Replication complex does move along DNA strand
False
Where are replication complexes in eukaryotic cells
anchored to the nuclear matrix
What are telomeres?
DNA sequence at the end of chromosomes
True or false: telomeres do not contain genes
true
What is the purpose of telomeres
cockblocks different chromosomes
prevents incorrect signaling
delays gene shortening
What can replace lost telomere sequences
telomerase, stem/germ cells/most cancer cells
What is telomerase
enzyme that replaces telomeres
What are the 3 DNA repair mechanisms
proofreading, mismatch repair, excision repair
What is proofreading
corrects errors during DNA replication
What is a mismatch repair
several proteins look for mismatched base pairs
When does mismatch repair occur
after replication
What is excision repair
damaged nucleotides are removed
Note 
Flashcard (73)