microbio exam 3 iclicker 2

Practice vocabulary flashcards based on lecture questions regarding the adaptive immune system, lymphocyte activation, and antibody mechanisms.

_______ is/are a hallmark feature of adaptive immune responses. (Select all that apply)

Memory and Specificity

Which of the following would be the most immunogenic to a human?

Horse albumin and large protein

During their maturation process, lymphocytes can be eliminated _________. (Select all that apply)

a. if they fail to produce a functional receptor and b. if they produce autoreactive receptors

In the process of clonal selection, pathogen binding to a preprogrammed receptor selects the lymphocyte that will undergo clonal expansion to produce the army of immune cells leading to its destruction.

True

Class I and II MHC molecules combine with antigen fragments to form a ______ which then binds a T cell receptor leading to activation.

neoantigen

A ________ has a CD8 coreceptor and eliminates viral-infected cells, cancer cells and foreign cells.

Cytotoxic T cell

A neoantigen used to activate a TC cell is made by the lysosomal degradation of a phagocytized antigen which binds a Class II MHC molecule.

False

A proteasome ___________. (Select all that apply)

degrades viral proteins, making fragments to load into Class I MHC molecules

TCR binding to both processed antigen and portions of an MHC molecule is known as ___________.

associative recognition

What cytokine plays a major role in both the early and later stages of T cell activation?

IL-2

Memory cells lead to rapid pathogen elimination on subsequent exposures due to __________. (Select all that apply)

b. their systemic distribution and c. their increase in number by self-renewal

How large is the induration produced by this positive Mantoux tes?

1cm

Antibody effector mechanisms include _________. (Select all that apply)

a. mast cell activation and b. enhanced opsonization

Which antibody classes provide natural passive immunity to infants? (Select all that apply)

a. IgG and b. IgA

The coagulase assay to rapidly identify Staphylococcus aureus uses antibody structure to cause coagulation.

False

Which of the following are components of the BCR? (Select all that apply)

b. IgM and d. Igα/Igβ

Binding of a pathogen to the sIg of a BCR complex causes conformational changes in other complex components exposing cytosolic enzyme-binding domains that results in intracellular signaling.

True

Which of the following binding events occur during T-dependent B cell activation? (Select all that apply)

a. Associative recognition with a neoantigen,

b. CD40/CD40L,

c. B7/CD28,

d. IL-2/cytokine receptor

Affinity maturation results in increasing more effective antisera production due to ______. (Select all that apply)

b. somatic mutation leading to higher antibody affinity

d. activation of memory cells with high affinity receptors

During a secondary response__________. (Select all that apply)

b. IgG production occurs almost immediately

c. there is a greater amount of IgG produced

d. the host demonstrates immunity

Which antibody effector mechanism results in apoptosis?

d. Antibody-dependent cell-mediated cytotoxicity