The Opioids I: Poppies, Pain & Pharmacokinetics

Flashcards covering key concepts and details from the lecture on opioids and their pharmacokinetics.

The plant source of all natural opiates is __.

Papaver somniferum

__ is a common side effect of opioids characterized by reduced bowel movement.

Constipation

A popular opiate medicine in the 1800s, composed of opium, wine, and spices, is known as __.

Laudanum

The hypodermic needle was invented in __.

1844

The Harrison Narcotics Act, which strictly regulates opiate products, was enacted in __.

1914

Heroin is chemically modified morphine which was created by Bayer Co. in __.

1908

The half-life of morphine is approximately __ hours.

3-5

__ are natural peptides that have morphine-like properties in the body.

Endogenous Opioids

Mu receptors, which provide the strongest analgesia effects, are primarily found in the __.

dorsal horn of spinal cord

The 'Gate Control Theory of Pain' explains how __ can modulate pain signals in the spinal cord.

brain modulation