targeting transcription and protein synthesis

Antibiotics targeting transcription

Rifamycin

What does Rifamycin inhibit

synthesis of messenger RNA (encodes protein)

how does Rifamycin inhibit synthesis of mRNA

Rifamycin targets RNA polymerase

what does rifamycin do to tissues

penetrates tissues

side effects of Rifamycin

Red urine, saliva, sweat, or tears

protein synthsis/ translation inhibitors: Aminoglycosides effective against

gram negative bacteria

what can Aminoglycosides cause damage to

auditory nerve and kidneys

Protein Synthesis/ translation Inhibitors: tetracylines effective against

broad spectrum ( both gram + and gram -)

pro of Tetracylines

has long retention in body and long penetration

what is Tetracylines used in

animal feed (bad)

Tetracylines side effects

Discolor teeth in children and not given to pregnant women (liver damage)

Tetracylines example

doxycycline

Protein Synthesis/ translation Inhibitors: Chloramphenicol effective against

broad spectrum (gram + and gram -)

what is a problem with Chloramphenicol

toxicity problems

pros of Chloramphenicol

inexpensive and ready diffusion

what can Chloramphenicol cause

aplastic anemia

protein synthesis/ translation: macrolides effective againsnt

gram positve

what is macrolides

oral antibiotic for children

example of marcrolides

erythromycin