Patho- adaptive immune system

naturally acquired active immunity

antigen enters body, antibodies are produced

artificial active immunity

antigens in vaccines, antibodies produced

artiificial passive immunity

immune serum with antibodies, animal venom

cells that provide an early cytokine-mediated warning system

immature dendritic cells

iDCs are constantly processing antigens until

activated thru pamps or tlrs

DCs present antigen on _______ molecules to CD8 t cells

MHC class I

which MHC class presents to CD4 t cells

MHC class II

MHC I is in all ___ cells

nucleated

what type of antigens are are processed in MHC I

endogenous

MHC Class I presents peptides degraded by a _______. these peptides are then shuttled thru the ___ and it binds to the groove on MHC I

proteosomes. ER.

MHC II molecules are on what type of cells

APCs (dendritic cells, macrophages, b cells)

MHC II presents peptides that are ________ and acquired through ______

exogenous, engulfment

peptides are degraded in what part of APCs for MHC class II

lysosomes

T cells are made in the _____ and mature in the _____

bone marrow, thymus

what types of t cells are forced into apoptosis during selection

cannot interact with MHC molecules or react with host cells

cd4 t cells are the ____ cells that control

helper, inflammatory and immune response

the activation between t cell and MHC II is strengthened by

cd4 using its own part to bind to mhc, costimulatory signal CD28 and B7

cytokines determine whether cd4 becomes

TH1 or TH2 reponse

CD8 t cells are costimulated by

IL-2

cd8 t cells secrete

perforin and granzymes

TH1 cells secrete what two things

IL-2 (positive feedback) and IFN-y

TH1 response occurs ___ and amplifies ____ responses.

early, local

th1 activates what three things with IFN-y

macs, nk cells, cd8

TH1 eliminates ______ pathogens. it promotes what to combat things

intracellular. inflammation and cytotoxicity

TH1 mediates what type of hypersensitivity

IV

TH2 response occurs ___ and its systemic

later

what reinforces th2 response

IL-4 (positive feedback)

TH2 response stimulates differentiation of ______ and antibody____

b cells, class switching

TH2 ___ inflammation

limits

b cells that have cell surface antibody present antigen to

TH2 T cells

cd8 t cells are part of the ____ repsonse

th1

naive cd8 t cells are stimulated to grow by

il-2 because of th1 response

b cells produce

antibody

t cells conduct ____ immunity and b cells conduct ___ immunity

cell mediated, humoral

5 classes of Igs

IgG igA igM igE igD GAMED

predominant antibody in serum

IgG

which antibody crosses placenta, opsonizes, and activates complement pathway

IgG

predominant antibody. at mucosal surfaces, is a dimer, and switches to TGF-b

IgA

first antibody made during response

IgM

which antibody is pentameric

IgM

which anitbody binds to mast cells and basophils and is important for parasitic infections

IgE

which anitbody mediates type I hypersensitivty reaction

IgE

whihc anitbody’s function is mostly unknown but its in low plasma levels

IgD

which antibody circulates in blood

IgG

which anitbody causes pathogens to clump toehter

IgA

which anitbody plays a role in all infections

IgE

b cells differentiate into what or what

palsma cells or memory cells