Conventional Diabetes Therapies Effects

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1

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Increase Insulin Secretion

sulfonylureas, meglitinides, incretins

2

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Decrease glucagon secretion

incretins

3

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Appetite control

incretins

4

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Decrease glucose reabsorption

SGLT2 inhibitors

5

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Increase glucose uptake and utlilization

thiazolidinediones, metformin

6

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Lipotoxicity

thiazolidinediones

7

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Decrease hepatic glucose output

metformin, thiazodinediones