Kreb's Cycle

Step 1

Acetyl CoA + Oxaloacetate → Citrate

What Enzyme Catalyzes Step 1?

Citrate synthase

Step 2

Citrate → Isocitrate

What Enzyme Catalyzes Step 2?

Aconitase

Step 3

Isocitrate → Alpha ketoglutarate

What Enzyme Catalyzes Step 3?

Isocitrate dehydrogenase

What are the Products of Step 3?

• NADH (NAD+ → NADH)

• CO2

Step 4

Alpha-ketoglutarate → succinylCoA

• Most similar to the PDC

What Enzyme Catalyzes Step 4?

Alpha-ketoglutarate dehydrogenase

What are the Products of Step 4?

• NADH (NAD+ → NADH)

• CO2

Step 5

SuccinylCoA → Succinate

What Enzyme Catalyzes Step 5?

Succinyl-CoA synthetase

What are the Products of Step 5?

• GTP

Step 6

Succinate → Fumarate

What Enzyme Catalyzes Step 6?

Succinate dehydrogenase (flavoprotein)

What are the Products of Step 6?

• FADH2 (FAD → FADH2)

Step 7

Fumurate → L-malate

What Enzyme Catalyzes Step 7?

Fumarase

Step 8

L-malate → oxaloacetate

What Enzyme Catalyzes Step 8?

L-malate dehydrogenase

What are the Products of Step 8?

• NADH (NAD+ → NADH)