psychotic disorders

conventional/first-generation antipsychotic prototype

chlorpromazine

conventional/first-generation antipsychotic common suffix

-azine

first-generation antipsychotics mostly block what while second block what?

positive symptoms; positive and negative symptoms

first-generation antipsychotic adverse effects (4)

acute dystonia, parkinsonism, akathisia, and tardive dyskinesia

which EPS is a crisis situation?

acute dystonia

acute dystonia

tongue, neck, face, and back spasms and possible respiratory depression

akathisia

unable to be still, pacing, and agitation

tardive dyskinesia

involuntary movements of the tongue and face

how is acute dystonia and other EPS treated?

anticholinergic meds/benztropine

how is tardive dyskinesia treated?

valbenazine

another large adverse effect of first-generation antipsychotics is…

NMS

is NMS an emergency? what are the symptoms? (6)

yes; fever, CV issues, muscle rigidity, diaphoresis, change in LOC, and coma

antipsychotics are contraindicated in _______, especially in the _______ population

dementia; elderly

use what to screen for EPS

Abnormal Involuntary Movement Scale (AIMS)

depot preparations benefits with antipsychotics

lower AE and and decrease TD risk

antipsychotic meds do not cause…

addiction

second-generation/atypical antipsychotic prototype

risperidone

second-generation/atypical antipsychotic common suffixes

-idone/zapine/apine

second-generation antipsychotic benefit

less AE and EPS

second-generation antipsychotic adverse effects (6)

metabolic effects, orthostatic hypotension, CNS effects, mild EPS, sexual dysfunction, and elevated prolactin

aripiprazole (2nd gen) form

long-acting injectable

antipsychotic cost

expensive