All about BDNF

BDNF

Brain-Derived Neurotrophic Factor

Function – neuron survival

Helps neurons resist stress and apoptosis

Function – neurogenesis

Promotes growth of new neurons

Function – synaptic plasticity

Enhances connections between neurons

Function – differentiation

Supports maturation of neural stem cells into functional neurons

Importance – learning and memory

High BDNF improves long-term potentiation (LTP) and cognitive function

Importance – mood regulation

Low BDNF is associated with depression

Importance – neuroprotection

Protects neurons from injury or degeneration

Lifestyle – exercise

Physical activity increases BDNF levels and promotes brain health

Lifestyle – enriched environment

Stimulating environments enhance BDNF and support learning

Lifestyle – diet

Certain diets (omega-3s

Signaling pathway

BDNF binds to TrkB receptors

Clinical relevance

BDNF dysregulation implicated in neurodegenerative diseases