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Neuron
Electrically excitable cell that processes and transmits information; core building block of the nervous system
Resting potential
The voltage inside a neuron (-70mV) relative to outside when the cell is not being stimulated
Depolarization
Sodium (Na+) flows into the cell, making the inside more positive
Repolarization
Potassium (K+) flows out of the cell, bringing voltage back down after depolarization
Hyperpolarization
Voltage drops below resting potential before returning to baseline
Action potential
All-or-none electrical signal that fires once a neuron reaches critical threshold (~-45mV)
Refractory period
Brief period after an action potential during which another cannot occur
All-or-none principle
An action potential either fires completely or not at all — no partial firing
Synaptic vesicles
Structures that release neurotransmitters into the synapse after an action potential travels down the axon
Photoreceptors
Rods and cones; the only retinal cells directly sensitive to light
Photoisomerization
Process by which light is converted into a neural impulse via photopigment molecules
Pigment epithelium
Layer behind the retina that supplies blood/nutrients to photoreceptors and enables photopigment regeneration
Bipolar cells
Retinal cells that relay signals from photoreceptors to ganglion cells
Ganglion cells
Retinal cells whose axons form the optic nerve
Horizontal cells
Retinal cells that mediate lateral interactions between photoreceptors
Amacrine cells
Retinal cells that mediate lateral interactions between bipolar and ganglion cells
Blind spot
Area with no photoreceptors where the optic nerve exits the eye
Rods
Photoreceptors for dim light/night vision; ~100 million per eye; absent from fovea
Cones
Photoreceptors for color/daylight vision; ~5 million per eye; densest at fovea
Fovea
Retinal region with only cones, responsible for sharp central vision
Dark adaptation
Gradual increase in visual sensitivity in low light as rods take over from cones
Purkinje shift
Shift in peak sensitivity from cones (long wavelengths) to rods (short wavelengths) during dark adaptation
Spatial summation
Multiple rods converging onto a single ganglion cell, increasing sensitivity but reducing acuity
Visual acuity
Ability to see fine detail, best supported by cones in the fovea
Receptive field
Area of sensory surface that, when stimulated, changes a neuron's activity
Center-surround organization
Receptive field structure where center and surrounding area have opposing effects (excitatory/inhibitory)
Simple cells
V1 cortical cells with on/off areas responding best to bars of light at specific orientations
Complex cells
Cortical cells responding to light/dark stimuli and edges regardless of exact location in receptive field
End-stopped cells
Complex cells sensitive to the length of a stimulus
Feature detectors
Specialized neurons/cell groups that respond only to specific stimulus features (orientation, motion, color)
Lateral geniculate nucleus (LGN)
Thalamic relay structure with 6 layers that processes visual input before it reaches the cortex
Magnocellular layers
LGN layers 1-2; involved in detecting movement and flicker
Parvocellular layers
LGN layers 3-6; involved in color and form perception
Retinotopic mapping
Organization where location of neural activity corresponds to location of stimulus on the retina
Cortical magnification
Disproportionately large area of visual cortex devoted to processing foveal input
Orientation columns
Groups of V1 neurons organized by their preferred stimulus orientation
Lateral inhibition
Neural circuit where stimulated neurons reduce activity of neighboring neurons, sharpening contrast
Simultaneous contrast
Illusion where surrounding background affects perceived brightness of a central region via lateral inhibition
Hermann grid illusion
Illusion of gray blobs at intersections of white lines on a black grid, caused by lateral inhibition
Mach bands
Illusory bright/dark bands at edges of a gradient, caused by lateral inhibition enhancing contrast
Dorsal stream
"Where/how" visual pathway to parietal cortex; involved in motion, location, and action
Ventral stream
"What" visual pathway to inferotemporal cortex; involved in object identification, form, and color
MT (medial temporal area)
Brain area with neurons tuned to motion and direction
V4
Visual area involved in color and curved-edge/form processing
Inferotemporal cortex (IT)
Area where neurons respond to complex shapes; final stage of ventral "what" pathway
Fusiform face area (FFA)
Brain region specialized for face recognition
Extrastriate body area (EBA)
Brain region specialized for recognizing body parts
Parahippocampal place area (PPA)
Brain region specialized for recognizing places/scenes
Binding problem
The challenge of how the brain integrates separate features (color, shape, motion) into one perception
Population coding
Using activity across multiple neurons (rather than one) to represent a stimulus unambiguously
Single cell recording
Research method recording electrical activity of individual neurons, typically in animals
PET (Positron Emission Tomography)
Brain imaging measuring blood flow; poor spatial and temporal resolution, involves radioactivity
fMRI (functional MRI)
Brain imaging measuring blood oxygen levels; good spatial resolution (voxels)
Voxel
3D pixel used in fMRI, representing about 100,000 neurons
Diffuse Optical Tomography (DOT)
Portable brain imaging method measuring blood oxygen via reflected light
Psychophysics
Study of the relationship between physical stimulus intensity and perceptual experience
Absolute threshold
Minimum stimulus intensity needed to detect a sensation
Difference threshold (JND)
Smallest detectable difference between two stimuli; just noticeable difference
Method of limits
Threshold method presenting ascending/descending stimulus series to find point of response change
Method of adjustment
Threshold method where subject/experimenter continuously adjusts stimulus intensity
Method of constant stimuli
Threshold method presenting a fixed set of intensities in random order across many trials
Staircase method
Efficient threshold method that reverses direction of intensity change based on responses
Point of subjective equality (PSE)
Stimulus intensity judged equal to the standard 50% of the time
Point of objective equality (POE)
The actual physical value of the standard stimulus
Size-weight illusion
Illusion where the larger of two equal-weight objects feels lighter
Weber's Law
JND is a constant proportion of stimulus intensity (JND = k × I)
Fechner's Law
Perceived intensity increases as a slower (logarithmic) function of physical intensity
Stevens' Law
Power function describing relationship between physical stimulus magnitude and perceived intensity, more broadly accurate than Fechner's Law
Magnitude estimation
Method where subjects assign numbers to stimuli relative to a standard, used in Stevens' Law
Signal detection theory
Framework for measuring sensitivity to a stimulus independent of response bias
ROC curve
Receiver Operating Characteristic curve; plots hit rate vs. false alarm rate to assess sensitivity
Hit rate
Proportion of correct detections of a signal
False alarm rate
Proportion of times a signal is reported when none was present
stevens’ power law

isosensitivity curve

dendrites

a
nucleus

b
cell body

c
myelin sheath

d
axon

e
axon terminals

f
cornea

1
iris

2
lens

3
sclera

4
retina

5
fovea

7
blind spot

8
optic nerve

9
ciliary muscle

12
parasol RGCs
retinal ganglion cells that form the basis of the dorsal (where/how) pathway
midget RGCs
retinal ganglion cells that form the basis of the ventral (what) pathway
MT (medical temporal area)
dorsal stream area with neurons tuned to motion direction and speed; tested using stimuli with dots moving randomly vs coherently
pariteal cortex
dorsal stream endpoint; processes “where” information —> direction and location
V4
ventral stream area with neurons selective for wavelength (color) and form, especially curved edges
ventral stream damage effect
patients cannot identify objects but can still draw them from memory, showing ventral stream is specific to object identification, not general vision
slot task
task used to test dissociation between perceiving an objects orientation (ventral) and acting to insert a card into it (dorsal)
dissociation between perception and action
finding that a persons verbal judgement (ventral) and their hand’s motor response (dorsal) can rely on different, sometime conflicting, info
ebbinghaus-type size illusion (disk experiment)
experiment showing that even when two disks are perceived as equal size (ventral), the hand’s grip size scales to their true size when reaching (dorsal)
binding problem
the challenge of how the brain combines separate neural info about color, shape, and motion into one unified perception