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What type of virus is Ebola?
Filovirus (threadlike)
RNA - replicates quick
Where did it emerge from?
Africa
Does ebola have a high mortality rate?
Very high
50-80%
What is a mystery about this?
Its natural reservoir is unknown
What does it mean that it is hemorrhagic?
Infects many cell types
damaged endothelial cells lining blood vessels
What was the Zarie outbreak in 1976?
Happened in the Catholic mission church, village Yambuku
caused bloody vomiting, nosebleeds, bloody diarrhea
similar to Marburg
DO NOT KNOW HOW ITS TRANSMITTED
had other small outbreaks in ‘77 and ‘79
Which strain caused the highest mortality rate?
Zarie outbreak
88%
Sudan outbreak 1976
Hemorrhagic manifestations 71%
mortality rate 53%
had another outbreak in 1979
Reston Ebola 1989
Killed all of the monkeys (macaques)
airborne transmission
not lethal to humans
1992 Tai Forest Ebola
Killed off chimpanzees and can infect people
Day 5 symptoms- vomiting, diarrhea, rash
How we discovered a new strain of Ebola