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drugs in class
valproic acid
divalproex Na (Depakote)
lamotrigine (Lamictal)
carbamazepine (Tegretol)
properties/MOA valproic acid
divalproex Na (Depakote)
· Works through the Na/Ca channels
· First line therapy
· Better tolerated & fast onset
Greater therapeutic index
effects/adverse rxn valproic acid
divalproex Na (Depakote)
· Thrombocytopenia
· Hepatotoxicity
· Pancreatitis
· Weight gain
· GI upset
Teratogen
contraindications valproic acid
divalproex Na (Depakote)
Contraindicated w/ pregnancy
nursing info valproic acid
divalproex Na (Depakote)
· Monitor plasma levels q6 months
Take w/food
effects/adverse rxn lamotrigine
· Stevens-Johnson rash
→ If dose is too high, too fast
nursing info lamotrigine
· NO need to monitor plasma levels
· Gaining in popularity
Expensive
effects/adverse rxn carbamazepine
· Ataxia
· Vertigo
· HA
Leukopenia